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Anti -fever analgesic “ibuprofen” or kidney damage to children, have you eaten your child?Don’t use it randomly

Ibuprofen, many people should have heard its name. It is a non -sterite anti -inflammatory drug, which has a wide range of usage in the world.

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In the past, some scholars have stated that adults and children may increase the risk of acute kidney injury (AKI), but lack of data support for large -scale research.

Recently, a large -scale research on this issue has given a conclusion, which is the first large -scale queue study in China ’s ibuprofen use and hospital acquired AKI.

The study collected inpatient patients with 30,44023 ages between 1 and 18 years old, of which 50,420 children, the average age was 5 years old, 60.8%was boys.Among the inpatient children, after adjusting the mixed factors, the risk of “hospital obtaining sexual acute kidney damage” risks increased significantly, and they were dependent on dose.

Although ibuprofen is an analgesic solution to the heat and solving thermal drugs in the family, it is not possible to use it casually. The following is a detailed introduction to this medicine for everyone.

1. ibuprofen: Anti -painkillers with powerful effects

Ibuprofen has a strong analgesic effect. It is 16-32 times that of aspirin, and the drug mechanism is also very simple. It is mainly to reduce the synthesis of prostaglandin (PG) by inhibiting epoxyase (COX).Prostaglandin is related to the pain, heat, and inflammation reactions of the body. It can cause the local tissue to be congested, swollen, and fever, and enlarged the “pain” signal. Therefore, the synthesis of PG can achieve an analgesic effect.

Clinically, ibuprofen is commonly used to relieve some mild to moderate pain, such as headache, joint pain, migraine, toothache, muscle pain, neuralgia, dysmenorrhea, etc.In addition, it can solve the heat through the temperature adjustment center of the hypothalamus, especially for the effect of lasting high heat.

Not only that, it is also recognized as the first choice of anti -inflammatory drugs for children, which has obvious effects on rheumatism and rheumatoid arthritis, osteoarthritis, etc., but the anti -inflammatory effect is relatively weak.

It can be seen that the efficacy of ibuprofen is relatively powerful and the safety is relatively high, but if it is not used properly, there will also be serious adverse reactions.

2. It can be used, but it cannot be used randomly

As the research mentioned at the beginning of the article, blindly or excessive use of ibuprofen can increase the risk of acute kidney injury (AKI), which can seriously cause renal failure.Not only that, it can also cause adverse reactions such as diarrhea, nausea, vomiting, and increase severe cardiovascular events, such as myocardial infarction and stroke.

Therefore, we must remember the contraindications of ibuprofen, especially the contraindications of ibuprofen.

1. Patients with heart disease

Especially for patients who have just undergone heart bridge surgery, they must be disabled.Related studies have shown that taking ibuprofen every day can last for 7 days or more, which can increase the risk of 75%of heart disease.

2. Patients with gastrointestinal discomfort

Such as those who have a history of gastrointestinal ulcers, gastrointestinal bleeding or perforation, this medicine can stimulate the endometrium of the gastrointestinal and gastrointestinal blood, and it will also weaken its own repair ability.

3. Renalized patients

The drugs are mainly excreted through the kidneys. A large number of renal damage may occur in large quantities for a long time and aggravate the condition, so it is used with caution.

4. Patients with autoimmune diseases

Such as systemic lupus erythematosus, mixed connective tissue disease, etc., sterile meningitis may occur after taking.

5. Pregnant women

It may cause damage to the fetus and increase the risk of heart defects in the late pregnancy.

Therefore, although ibuprofen is a “good medicine”, it may become a “poison” by mistake. When taking it, you must master the correct method.

3. How to take ibuprofen correctly?

First, we must control the dose.Under normal circumstances, the adult dose is 400-600mg each time, and it must not exceed 2400 mg in 24 hours.In this scope, how many and how many times take it need to be determined according to the degree of inflammation, especially children, the liver development is not complete, the medication is more cautious, and the doctor’s guidance is required.

Second, pay attention to the time you take.Generally speaking, it is not allowed to be used for more than 3 days when solving heat, and it must not be applied for more than 5 days when it is used for pain relief.

Finally, do not use ibuprofen immediately as soon as headaches, fever, tooth extraction, and dysmenorrhea are used.No matter how safe the medicine is, it is best to consult a professional physician to see if it is necessary, appropriate, and follow the doctor’s order.

In general, ibuprofen is a highly safe drug in clinical applications, but it does not mean that it can be used casually. It is recommended that you carefully listen to the advice of doctors and pharmacists, and use it reasonably according to the recommended dose to ensure both effective and safe.

Further reading: ibuprofen, simple differences about acetaminophen, and painful tablets

Although ibuprofen, although the acetaminol, and pain tablets are painkillers, there are still differences between them, and the indications are different. Everyone pays attention to choosing the one that suits them to avoid cure for “disease cause”:

• Depending on the pain film

The price of this medicine is cheap, many people buy it, but they are more addictive.It contains addictive ingredients such as Naisiidin, phenobari, caffeine, etc., which can easily cause dependence and tolerance.Once discontinued, there may be manifestations of mental discharge, insomnia, diarrhea, sweating, vomiting and other manifestations.


It has a certain analgesic effect on headache and throat pain, but there is no anti -inflammatory effect, and the effect of inflammation -related pain is not as good as ibuprofen.

· Borufen

For patients with long -term medication and arthritis patients, this medicine can be used, but be careful not to take a large number of long -term use to avoid damage to the kidneys.But in comparison, security is higher than the previous two.Ibuprofen is a common medicine for daily life. Everyone is better to understand common sense in medicine in advance to avoid wrong medicines and reduce risks.Hope this article can help you.

Reference materials:

[1] Jama Network: There are more than 50,000 children in China, and ibuprofen can significantly increase the risk of acute kidney injury!. MEDSCI Mess. 201-3-6-6

[2] ibuprofen, as an analgesic anti -inflammatory medicine, how much do you know?. Shanghai Medicine News. 2019-06-03

[3] Brown, another “good medicine”?Inhibit or “poison”?.PSM Medicine Shield Charity. 2020-11-01

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