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Are single women frozen eggs?What do you use to save them?

“This is the only regret medicine in the world. It doesn’t matter if this medicine is eaten, but it is always right.” In 2015, Xu Jinglei publicly revealed that he had frozen 9 eggs abroad, which caused social attention for a while. Frozen eggs are like a maternity insurance for single women.

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Official response, one hammer?

On the evening of February 23, the National Health and Health Commission disclosed related proposals on the official website of the “unmarried women who allow unmarried women to preserve medical indications” during the 2020s during the 2020s A reply letter. It is clearly stated that “prohibit the implementation of human auxiliary reproductive technology for single women.” The State Health and Health Commission also said that it will study and formulate the technical specifications and relevant standards of egg frozen, scientifically and objectively promote the clinical application of egg frozen technology.

Picture source: Website of the National Health and Health Commission

Why can’t women “freeze eggs”? In a letter of response to the proposal, the National Health and Health Commission stated that the purpose of delaying fertility is not in compliance with the relevant provisions of my country’s laws and regulations. There are three main considerations: there are hidden health risks in applying egg frozen technology; the application of egg frozen technology for delay fertility is still controversial in the academic world; strictly preventing commercialization and maintaining social welfare is the ethics that need to be strictly followed by the implementation of auxiliary reproductive technology. in principle. The reason why the country formulates this policy may be the first cause to prevent illegal acts such as eggs and surrogacy. However, frozen eggs and surrogacy cannot be simply equal.

Existing fertility preservation technology, women’s fertility preservation international guide interpretation- “Practical Obstetrics and Gynecology Magazine” 2020 Issue 05, Naval Military Medical University Affiliated Long March Hospital Reproductive Medicine Center

Frozen eggs are the category of fertility preservation (FP). It refers to the ability to help women or men who use surgery, drugs or laboratory technology to protect and preserve their genetic offspring. The emergence and development of fertility protection disciplines are mainly due to the increase in the advancement of fertility protection technology and the increase in the main demand objects of fertility protection, that is, the youthfulness and survival rate of the onset of oncology patients have increased year by year.

Women’s fertility preservation technology includes technologies such as embryo frozen, ovarian frozen, ovarian tissue frozen, and mature in vitro. The frozen eggs often referred to refer to the medical technology of frozen and ultra -low temperature storage of egg mother cells to treat infertility and preserve women’s fertility for the purpose of fertility. Frozen eggs can prevent the eggs from aging with the human body. Can.

When a woman uses her partner’s sperm to fertilize, the embryo is frozen into the best fertility preservation method. In some cases, women take eggs from the ovaries before the cancer treatment, and then immediately freeze the embryo with their partner’s sperm after fertilization. More than 30 years ago, embryo frozen preservation technology has begun in early auxiliary reproductive technology. Nowadays, the effects of glass frozen embryo are implanted as fresh embryos in the artificial starting cycle of endometrial.

In recent years, with the research and practice of ovarian maternal cell glass, it has effectively improved the damage caused by the formation of ice crystals during the freezing process, and the thawing recovery rate has reached more than 90%. The increasing maturity of egg frozen technology has greatly promoted the application of egg frozen, and provided technical feasibility for the establishment of the egg library. In the 2013 American Association of Reproductive Medicine (ASRM), it is clear that the frozen -frozen eggs have been farewell to the experimental research stage. The glass -based freezer of oocytes will become the preferred technology for fertility preservation of non -tumor patients.

Compared to the protection of fertility, the protection of men’s fertility is more mature, and the main method of preservation of sperm frozen men’s fertility. Self -frozen deposit refers to the preservation of sperm (testicular, epididyie or semen). The preservation measures for fertility, the frozen stem cell frozen is still in the laboratory stage. The “Basic Standards and Technical Specifications of Human Sperm Studio” issued by the Ministry of Overseas has stated that: men can apply for semen based on “reproductive health care” or “need to preserve sperm for future fertility”.

According to data from the United Nations, women in Greece, Japan, and Sweden have an average of more than 30 years old, which is about 27 years old in 1970. The average marriage age in Germany, Canada, and the Netherlands has been steadily rising. Recently, according to data from the Ministry of Civil Affairs, 92 million people will live alone in 2021. With the intensification of single trends and late marriage trends, these demands are more obvious. At the two sessions of 2020, members of the CPPCC suggested that “giving single women to implement auxiliary fertility technical rights.”

The first single woman in the country strived to be tried in Beijing at the end of 2019. The party Xu Zaozao (pseudonym) said that on November 14, 2018, she went to a hospital to consult the “freezing egg” and passed the relevant examination to confirm that her body was normal and the eggs were healthy, but her “frozen eggs” demand was suffered. The doctor refused. To this end, Xu Zaozao brought the hospital to court. Xu Zaozao believes that this is a discrimination against her women’s identity, and she asked the court to order the hospital to provide “frozen eggs” services for it. “In the past one or two years, my work has been promoted, so I feel that there should not be a long time to leave the post at this time, because I will definitely be forced to invest in more energy in the future.” The core is the “Human Assistance Reproductive Technical Specification” revised by the former Ministry of Health (reorganized into the Health and Health Commission in 2018 “in 2003, which stipulates that” prohibits couples and single women who do not comply with national population and family planning regulations and regulations. Implement human assisted reproductive technology. ” That is to say, the medical authority does not allow an auxiliary reproductive technology for unmarried women, and frozen eggs are a kind of auxiliary reproductive technology.

At present, the “Administrative Measures for Human Assistance Reproductive Technology” promulgated by China in 2001 stipulates that only women with malignant tumors can remove the eggs and freeze the eggs before radiotherapy and chemotherapy and infertility. It has clearly stipulated that couples must be held, that is, a marriage certificate, ID card, and quasi -student certificate, and a couple with infertility can accept the auxiliary reproductive technology diagnosis and treatment.

The National Health and Health Commission clearly stated that “it is forbidden to implement human auxiliary reproductive technology for single women.” In fact, as early as 2013, the Shanghai Municipal Health and Family Planning Commission issued the provisions for the consideration of the safety of frozen eggs. Couples with a history of infertility and pregnancy assistance have failed to accept the failure on the egg retrieval date. In special circumstances, the frozen eggs are considered.

For the “Human Assistance Reproductive Technical Specifications”, it is not allowed to use artificial auxiliary reproductive technology (such as frozen eggs or test tube babies) in single female frozen eggs, and the National Health and Health Commission previously stated in an interview with China Daily that the relevant laws in my country and the laws and laws in China are also compared Without prohibiting single women’s fertility, the Health and Health Commission will strengthen investigation and research, gradually consolidate consensus, improve relevant laws, regulations and policies and measures, and effectively protect women’s fertility, employment and occupational development rights. Strictly speaking, the current laws in my country have not explicitly pointed out whether single women’s frozen eggs are illegal.

The control measures for frozen eggs are relatively loose

In 1986, Australia produced the first case of frozen eggs, which was nearly 10 years later than frozen embryo and frozen essence. At present, there are more than 200 children born through frozen egg technology, and there are only less than 20 domestic in China.

In Japan, there are no relevant legal and regulations, only guidelines that have no legal binding. The Japanese Reproductive Medicine Society only agreed that healthy single women can also apply for freezing to save their eggs in August 2013.

Related Japanese guidelines include: the maximum age of egg retrieval is 36 years (only for suggestions); those who need eggs know the consent of the eggs; they must handle frozen eggs in accordance with the self -willingness of the eggs; frozen eggs can only be used for the fertility of egg supply, and others are not allowed to be allowed to be allowed to be allowed to be allowed to be allowed use. Or, when the supply is willing to abolish and agree to scientific research, it is used for scientific research. In the case of the death of eggs, frozen eggs are abolished; when the supply of eggs exceeds the reproductive age, the supply can be abolished after the egg supply is notified.

In the 2013 Guide of the American Reproductive Medicine, the label of the experimental technology was removed by the egg frozen. For patients who faced infertility due to chemotherapy or other gonadotoxic therapy, it is recommended to adopt appropriate consultation and preserve egg mother cells. However, the safety and effectiveness of the frozen ovarian mother cells require more clinical data, and the general development of egg libraries for the purpose of supporting eggs. Oocytopenia frozes that simply delay the age of fertility lack sufficient evidence support.

In 2000, the British government revised the application of the law to make the application of frozen eggs legalized. However, the British artificial insemination and embryo science bureau stipulates that the preservation period of frozen eggs must not exceed 10 years to prevent some women from regenerating children over 50 years of age. However, in recent years, the human fertilization and embryo administration (HFEA) of the British regulatory agency has recognized this problem, and the Equality and Human Rights Commission also agreed to change the requirements of the current legislation. ASSISISTED REPRODUCTIVE Technology (Art) professionals and patients have strong hopes to change the current guide.

The US SCRC Southern California Maternity Center is located near Hollywood. It is one of the most successful clinics in the United States. In recent years, many Chinese women have chosen to frozen eggs here. Before 2015, the SCRC Southern California Grand Perfect Center received more than 200 Chinese customers, but from this year, the number of people has doubled to more than 500. From 2016, the center has received nearly 1,000 Chinese customers.

How much knows frozen eggs?

Most women are excreted only one mature egg every month (this is why normal pregnancy is mostly single). If frozen eggs are to be performed, women need to take ovulation-promoting drugs to make multiple follicles develop at the same time, and then use a 35cm long and diameter of 1.6-2.2mm. Pass through the vaginal dome, reach the ovarian, puncture the follicles in the ovaries, and suck out the follicular fluid and the eggs in negative pressure. Eggs can be tied or no anesthesia. Egg pins of different models

Egg section diagram

After the eggs are removed, frozen in the liquid nitrogen below 196 ° C. When preparing for pregnancy, if it is thawed, frozen eggs will move like fresh eggs. Technically, frozen eggs have no time limit, but internationally clinically preserved for 5 years.

As early as 2011, a large -scale study of women of childbearing age cancer was shown that the maternity consultation and fertility preservation before treatment can improve the quality of life (QOL) of patients with cancer patients in childcare age. Therefore, the fertility preservation of cancer patients can not only increase the pregnancy rate, but also have benefits to cancer patients themselves.

Preservation of fertility is undoubtedly the best choice to solve the problem of fertility needs and tumor treatment. Researchers at the Karolinska College of Sweden in the “Jama Oncology” magazine of the American Medical Association emphasized the important sex.

In this forward -looking queue study, in groups with fertility, fertility and auxiliary reproductive therapy are 2.3 times and 4.8 times of the control group, respectively. The cumulative incidence of live production 5 years after the diagnosis of breast cancer is 19%and 9%among women without FP history, and 41%and 16%after 10 years. For the first living production after diagnosis of breast cancer, at least 20%of the FP (fertility) group has at least 20%of pregnancy. The control group has 4%of pregnancy through auxiliary reproductive (ART).

Cumulative incidence of breast cancer and mortality (calculated according to the number of years after the diagnosis)

REPRODUCTIVEOUTCOMES after Cancer in WOMEN With vs Without Fertility Preservice.jama Oncology: 10.1001/Jamaoncol.2020.595777

The results show that the long -term reproductive results of women who are diagnosed with breast cancer are generally gratifying. As early as the “Human Assistance Reproductive Technical Specifications” promulgated by the Ministry of Health in 2003, the adaptive group of in vitro fertilization-embryo transplantation and an auxiliary reproductive technology such as an internal sperm micro-injection in the ovarian pulp People who have special diseases affecting future fertility and other conditions.

“Human Auxiliary Reproductive Technical Specifications”

The preservation of fertility has become a seed in the hearts of everyone with fertility needs, but there is no real regret medicine in the world, and the preservation of fertility can not guarantee that every expectation can have a perfect ending. According to statistics, a healthy and fertility 30 -year -old woman has a chance of pregnancy of 20%, and at the age of 40, the chance of pregnancy per cycle is less than 5%.

From the perspective of eugenics, it is recommended to marry and fertility, consider the relationship between life and work, and reasonably arrange family fertility plans. In the best age, there is no regret for life.

We also look forward to further establish and improve relevant laws and regulations, promote the healthy and healthy development of egg frozen technology, and allow women to be effectively met in a reasonable range.

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