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BMC subsidy: coffee control benefits -1/4 people in the world can people live?Drink more coffee!

Chronic liver disease (CLD) is a major health issue in the world. From 1990 to 2017, the number of people died in the world increased from 899,000 (1.9%of the total population) to 1.32 million (2.4%). During the same period, the number of disability adjustments due to CLD increased from 30.5 million to 41.4 million.

In low -income countries, CLD’s burden is higher, and the treatment plans of these countries are also limited. South Africa is the most affected area, followed by Central America and South America, Eastern Europe and Southeast Asia. The most common cause of CLD is alcohol -related liver disease (ALD), chronic hepatitis B and hepatitis C infection, and non -alcoholic fatty liver (Nafld).

The above situation involves the destruction and regeneration of the liver, leading to liver fibrosis, and then liver cirrhosis. Due to the development of complications, liver failure, or hepatocytal carcinoma (HCC) related to door vein hypertension, liver cirrhosis may be fatal. Among them, data show that the incidence and epidemic rate of the global NAFLD have risen rapidly, which has reached 25%.

Coffee is a popular beverage in various regions around the world. It consists of hundreds of chemicals, including caffeine, chillic acid, and coffee melol. Observation and laboratory studies have shown that drinking coffee has a protective effect on CLD, including cirrhosis and HCC. This effect has been observed among people who drink caffeine -containing coffee and coffee, which is small, and drink -free caffeine.

Although drinking coffee is related to the incidence of lower CLDs, people have little influence on different types of coffee, because the chemical components of different coffee are different. In order to evaluate different coffee, including the relationship between caffeine -free coffee, quick -soluble coffee and grinding coffee and CLD results, related studies were carried out from the University of Southampton University of Medicine, and the results were published in the BMC Public Health magazine.

This study analyzed the data in the UK BIOBANK (UK BIOBANK), including 49,4585 participants who were known to drink coffee and had electronic contact with hospitals, death and cancer records. According to different types of coffee drinking conditions, CLD is estimated to occur with CLD, CLD or fat degeneration, and the risk ratio (HR) of HCC and CLD death.

Of the 384,818 coffee people and 109,767 people who did not drink coffee, 3600 CLDs, 5439 CLD or fat degeneration, 184 HCC and 301 CLD deaths occurred, and the median follow -up time was 10.7 years. Compared with people who do not drink coffee, the risk of CLD (HR = 0.79, 95%CI 0.72-0.86) is reduced by 21%, while the risk of CLD or fat degeneration is reduced by 20%(HR = 0.80, 95, 95 % CI 0.75-0.86).

Similarly, due to CLD death caused by coffee, the death of CLD was nearly half 49% (HR = 0.51, 95% CI 0.39-0.67), and the risk of HCC was reduced by 20% (HR = 0.80, 95% CI 0.54-1.19). Among them, the separate correlation between caffeine -free coffee, quick coffee and grinding coffee is similar to all types of combinations.

Further analysis shows that compared with a subject who does not drink coffee, the subjects of drinking grinding coffee have benefited more. CLD’s risk and death risk were reduced by 36%and 63%, CLD or liver fat degeneration risk decreased by 36%, and HCC risk was reduced by 38%.

In summary, all types of coffee have a protective effect on CLD. You can drink coffee as appropriate on the basis of your own situation.


All coffee types decrease the risk of adverse clinical outcomes in chronic liver disease: a UK Biobank study. BMC Public Health 21, 970 (2021).

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