Recently, a research article published a research article on British Journal of Cancer in the field of oncology. Researchers aims to evaluate the connection between breast cancer patients and healthy women’s weight index (BMI) and absolute lymphocyte counting (ALC).
In addition, researchers aims to clarify the prognosis of these factors in breast cancer.
The researchers retrospectively identified 1225 patients with native infiltrated breast cancer and 35,991 healthy women, and used the multi -variable COX proportional risk model evaluation of BMI and whole blood cell counts related to the disease -free survival period (DFS).
Through analysis, researchers have found positive correlation between breast cancer patients and healthy women BMI and ALC (P <0.001). In multiple variable analysis, compared with individuals with too light weight or normal weight, the DFS of overweight or obese participants is poor (risk ratio [HR] is 1.98; 95 % confident interval [CI] is 1.34-2.92; P = 0.001), but patients with higher ALC DFS are better than patients with lower ALC (HR is 0.43; 95 % CI is 0.29-0.65; P <0.001). After the risk layering of BMI/ALC, high -risk patients with higher BMI/lower ALC DFS are worse than other patients (HR is 2.48; 95 % CI is 1.70–3.62; P <0.001).
It can be seen that BMI and ALC are positively correlated, but their effects on the prognosis of breast cancer. Patients with higher BMI/lower ALC are worse than other patients. Future research should be discussed in response to the potential mechanism of BMI/ALC affecting the prognosis of breast cancer.
Sung Min Ko.et al.Body mass index and absolute lymphocyte count predict disease-free survival in Korean breast cancer patients.Brit J Cancer.2021.https：//www.nature.com/articles/s41416-021-01391-0