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Cardiovasc Diabetol: The higher the level of plasma phosphate, the higher the risk of death of diabetic patients!

As we all know, the risk of cardiovascular disease in patients with type 2 diabetes has increased significantly. Higher plasma phosphate levels can promote blood vessel calcification, which may adversely affect the prognosis of patients with type 2 diabetes. Researchers speculate that compared with non -diabetic patients, the correlation between the plasma phosphates of type 2 diabetic patients and their mortality may be stronger.

Researchers such as VAN DER VAART used the multi -variable COX regression of potential mixed factors to analyze the Lifelines queue based on the Dutch crowd and between the sub -group of the sub -group with type 2 diabetes and the mortality rate. Correlation.

The correlation between the level of phosphate and the risk of different people due to the risk of death

A total of 57,170 subjects were included, and the median followed up for 9.4 years. Compared with the minimum three-point (0.85-0.99 mmol/L) group in the phosphate, the highest three-point (1.00-1.83 mmol/L) group of the subject is higher due , P = 0.02). The state of the baseline 2 diabetes can significantly change the above correlation (P = 0.003). In the sub -group of type 2 diabetic patients (N = 1790), the risk of death of the highest three -point group of phosphates has increased significantly (compared to the middle three -point group, HR 1.73, P = 0.02). In the sub -group (N = 55380) with diabetes without diabetes, the level of phosphate level is not related to mortality (HR 1.12, P = 0.14). After excluding an individual with an estimated glomerular filtration rate below 60 ml/min · 1.73 m2, the results remain consistent.

The analysis results of EGFR <60 ml/min · 1.73 m2 were excluded

<!-2586: Diabetic terminal page

In summary, hypertrophic phosphate levels are related to the increase in mortality rates of patients with type 2 diabetes. In individuals without diabetes, this correlation is weak and unprecedented. Therefore, the level of plasma phosphate should be incorporated into the health monitoring items of patients with type 2 diabetes; in addition, reducing whether the level of phosphate levels can improve the health prognosis of patients with diabetes is worth further research.

Primitive source:

van der Vaart, A., Cai, Q., Nolte, I.M. et al. Plasma phosphate and all-cause mortality in individuals with and without type 2 diabetes: the Dutch population-based lifelines cohort study. Cardiovasc Diabetol 21, 61 (2022 ). https://doi.org/10.1186/s12933-022-01499-4

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