It is reported that the mother’s obesity is related to the neurological disorder of the offspring. However, potential mechanisms and effective intervention measures are still unclear. The School of Food Science and Engineering, Northwest China University of Agriculture and Forestry, has carried out related research, and the results were published in the recent Cell Metab.
The study aims to explore the mechanism connection between maternal obesity and childcare cognitive behavior defects, as well as the beneficial impact of dietary fiber on the defects of sub -generation. The cross-section study of 778 children 7-14 children in China shows that mother’s obesity is closely related to children’s cognition and social low.
Compared with the normal weight mother, the super heavy and obese children’s proportion of ultra -weight and obese mothers increase significantly (P <0.05). In addition, on average, the educational level and family income of overweight and obese mothers (P <0.001) are lower than normal weight. Linear regression analysis shows that after the variables of the association, the children of overweight and obese mothers before pregnancy and obese mothers have less scores in their social ability than children who have a normal weight before pregnancy (95%confident interval [CI]: -1.89 to -0.02).
Studies with queue studies in other countries have found that the children of obese mothers have poor cognitive ability, increased the risk of autism, and the social subjects and academic performance of Chinese mothers with overweight or obese children have significantly reduced their academic performance. This indicates that their social and learning ability is compared to Low (P <0.05). Studies also show that boys with significant social capabilities are more obvious than girls, which may be related to the low school performance (P <0.01). These data show that compared with female descendants, mothers in men's descendants are more likely to be related to cognitive and social obstacles.
In order to study the impact of mother obesity on the nerve development of the child, the study established an animal model: female C57BL/6J mice feed control feed (MCD) or high -fat feed (MHFD) for 12 weeks. As expected, MHFD significantly increased the weight of the mother (P <0.01). Female mice are paired with male mice to produce offspring, and then feed the diet (OCD) after weaning (3 weeks). During the behavior experiment, the weight of the child's dietary group at 8-10 weeks was not significantly different. There are no differences between the behavior of male and female offspring. In order to evaluate work memory and long -term memory, the Y maze test and novel object recognition test were performed. Compared with the MCD-OCD sub-generation, there are fewer spontaneous alternating offspring of MHFD-OCD, and the identification index of new objects and familiar objects is close to -0.2, indicating that work memory and long-term memory are damaged (P <0.01). The social capabilities of the descendants of MHFD-OCD have been damaged, and there is no preference for social novelty in the three-room social test. These data show that mothers' obesity can lead to decline in memory and social capabilities of future generations.
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In addition, studies have shown that the obesity of the mother and mouse disturbed the behavior of the offspring and the intestinal microorganisms. By reducing the defects of synapses and mature cells, a high -fiber diet can restore the behavior of the female or the sub -generation, and the intestinal microorganisms of the intestinal tract. group. The transplantation experiment of the co -residence and the fecal microbial region revealed the causal relationship between the microbial area and the change of behavior. In addition, the treatment of short -chain fatty acids derived from microorganisms also reduces the behavior defects of obesity offspring.
The study shows that cognitive and social dysfunction related to mother’s obesity is caused by changes in the sub -intestinal microbial region system. The intake of the dietary fiber of the maternal or sub -dietary dietary fiber can reverse behavior disorders by regulating the formation of bacterial composition and SCFA. Therefore, the significant changes in the microorganism ecosystem caused by obesity before pregnancy will provide new opinions on the awareness of future generations and social behaviors that have a negative impact. These results provide a deeper understanding of the impact of maternal obesity on the nerve development of the child. Children’s behavior abnormalities can be corrected before childbirth and after birth. Overall, this discovery opened a new research way for preventive treatment of neurospeittering in the maternal and/or the sub -intestinal microbial region system, and indicates that dietary fiber is a potential non -invasiveness, timely and timely, and Methods for easy treatment of neurological disorder.
原文出处：Liu Xiaoning，Li Xiang，Xia Bing et al. High-fiber diet mitigates maternal obesity-induced cognitive and social dysfunction in the offspring via gut-brain axis.[J] .Cell Metab， 2021， undefined： undefined.