Elife: Drinking beer hurts the liver!But beer hills may help treat liver disease!
Earlier researchers found that the ominol (xanthohumol) and its synthetic derivatives tetrahydrocarm-infantol (TXN) can slow down the obesity and metabolic syndrome of mice induced by high-fat diet. A simple structure containing a benonoid substance with gobolic groups. Recently, an article published on the research report entitled “Tetrahydroxanthohumol, A XANTHUMOL DERIVATIVE, ATTENUATES HIGH-FAT DIET-Intagonizing PPARγ”, from the study report of the research report from the science of the universities of the universities of the universities of the universities of the universities of the universities of the universities in Outania State University. A pair of compounds from beer may help block the accumulation of dangerous fat in the liver, that is, hepatic steatosis.
Related research results are very important, because liver fat degeneration affects the health of nearly a quarter of people in the United States and Europe. Although a large amount of alcoholic drinking is directly related to liver problems, people who rarely drink or have no history of drinking may occupy the patients with the disease. 25%, this is why these diseases are called non -alcoholic fatty liver (Nafld). Tolerance for insulin is a risk factor that occurs in Nafld. Insulin can help control the blood glucose level of the body; and rising fat levels in obesity, high -fat diet and fat in the blood are also risk factors that induce NAFLD. The liver can help the body to handle nutrients from the outside and play the filter of the body circulatory system. However, excessive fat in the liver may cause inflammation and liver failure.
In this study, researchers used mouse models to study that the heyphenols (XN) and tetrahydrochemol (TXN) could help slow down the accumulation of fat in the liver induced by diet. XN is a kind of isoplate flavoid produced by beer flowers, while beer flower is a plant that gives beer flavors and colors, and TXN is a hydrogen derivative of XN. In the article, the researchers randomly distribute 60 mice to one of the following five groups, namely a low -fat diet group, a high -fat diet group, a high -fat diet group that supplements XN, and supplemented more XN high -fat diet Group and supplement TXN’s high -fat diet group.
It was found that TXN could help suppress the weight gain related to high -fat diet, and at the same time stabilized blood sugar levels. Both factors would block the accumulation of fat in the liver. Researcher Professor Gombart said that TXN can very effective inhibit the occurrence and progress of liver fat degeneration caused by diet; and it seems to be more effective than XN, because high -level TXN seems to be accumulated in the liver, but XN is higher in higher The dose may slow the progress and symptoms of the disease. The mechanism behind this compound effect mainly involves PPARγ, which is a nucleus protein that can help regulate gene expression. PPARγ can also control the metabolism of glucose and storage of fatty acids. Fat cells.
XN and TXN may be used as an antagonist of PPARγ, which will be combined with protein and does not make it play. This is different from the PPARγ agonist, and the latter can activate it and combine it. In this case, the result of antagonism is the decrease in fat agglomeration in the liver. Researchers said that PPARγ in the liver may stimulate the storage of the body’s lipids; the results of this study are consistent with some research. In these studies, the weaker PPARγ agonist More effective, in other words, the lower level of PPARγ in the liver may have certain benefits. TXN is more good at accumulating in the liver than XN. This may explain why it can be more effective in reducing lipids, but the differences in the accumulation of the organization are currently not fully understood by researchers.
Researchers Gombart said that this may be because XN can be more effective in the host and its intestinal microbial group than TXN. Of course, this requires additional research to clarify. Although XN and TXN can be used as effective preventive measures used in rodents, researchers need to determine whether this new type of compound can help treat human obesity.
The results of this article show that the antagonistic effect of PPARγ in the liver may be the rational method of preventing and treating diet -induced liver fat degeneration and its related metabolic syndrome. Later researchers will further research to develop XN and TXN as a low Treatment of cost. In summary, the results of this article show that XN and TXN may be used as antagonists for PPARγ.
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