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Extremely low protein diet can help lose weight

There is still controversy about the relationship between the constituent and weight control of food and weight control. Many previous studies were concerned about fat and carbohydrates, but recently, the effect of protein has been paid attention to in protein leverage hypothesis. Protein leverage hypothesis shows that animal intake is mainly to meet protein targets. Therefore, it predicts that with the decline of diet protein levels, the body will excessively consume energy, resulting in excess energy and obesity.

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In mice, researchers have found that when the content of diet protein changes between 5%and 30%, the energy intake or body composition does not have significant correlation. This is in sharp contrast to other studies that show the study of diet protein content that drives food intake and fat content. In the above studies, the food intake of mice with the lowest protein level increased a small amount of food intake. It may be possible that the researchers have not reduced the protein content to a sufficiently low level to reveal the influence of protein on intake and fat. Essence

Protein leverage predicts predict that low diet protein will increase the overall energy intake and cause fat accumulation. Recently, the researchers designed 10 diets, combining protein from 1%to 20%with 60%or 20%fat. The results showed that the extremely low protein diet did not cause food intake.

For mice who feed a low -protein diet, regardless of the fat content in the diet, the body fat decreases, the level of leptin decreases, the leptin signal system is complete, and the hunger signal in the brain rises. However, they eat less foods. When they are released from dietary manipulation, they do not show hypertrophic appetite. As the MTOR signaling pathway of the Humana brain has also been widely changed by low protein levels, the researchers speculate that the channel may act on the downstream of the classic hunger signal channel to prevent the increase in food intake.

AAV-S6K1 in the brain room can significantly passivation of the food intake and weight loss of mice with 1%protein. This effect is not observed in suppressing EIF2A, TRPML1, and FGF21 signals. In addition, the effect of extremely low protein diet can be simulated by laptopycin.

Therefore, the 1%protein diet is partially dependent on the MTOR signaling mechanism of the lower mills, and the reduction of food intake and decreased weight.

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