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Four cases, take you to avoid children’s medicine!

At present, children’s special medicines are lacking. Sometimes children’s medication has to use adult medicines, and the children’s age, weight, and body surface area are converted into children’s dosage doses to give them to children.

In addition, children’s medication is different from adults. It is difficult to cooperate with the caregivers when swallowing poor ability to swallow. Therefore, children’s medication must not only be suitable for diseases, but also choose the appropriate dosage form.

Today, the editor compiled the common oral administration errors and solutions for clinical children’s common administration for clinical medication for the reference of clinical medication.

Case number one

Case

Children, female, 4 years old.

diagnosis

Helicobacter pylori infection.

Medication

15mg QD PO of Omeprazole entericolate tablets (20mg*12 tablets).

Medication analysis

Omeprazole is a proton pump inhibitor, and has become the preferred drug to treat related diseases such as digestive ulcers and gastroesophageal reflux disease. This product is a fat -soluble weak alkaline drug, which is easy to gather in an acidic environment. However, due to the unstable structure of the structure, it is generally used to protect the drug from the destructive degradation by using enteric -soluble jackets, and at the same time delay the absorption of the drug.

Therefore, in order to avoid affecting the efficacy, the intestinal soluble agent should be completely swallowed. Don’t chew, let alone crush and add food. Because the dose of the child is 3/4 tablets, the medicine should not be taken.

solutions

Some manufacturers of Omeprazole intestinal solunts mentioned in the manual that “if there is difficulty swallowing, you can use water or juice to dissolve the enteric soluble slices within 30 minutes.” Drink 3/4 in a minute, and abandon it.

In addition, the latest prescription (compound omeprazole mixed suspension) uses sodium bicarbonate to cushion the effect of gastric acid on gastric acid, so that it can quickly absorb in the stomach, play a role, and inhibit the secretion of gastric acid. This dosage form can solve the trouble caused by the dose segmentation.

Case 2

Case

Children, female, 8 years old.

diagnosis

asthma.

Medication

Meng Lu Ste sodium chewing tablets, (10mg*5 tablets), 5mg QD PO;

Buddinedefomo inhaled powder fog (60 suction*1), 1 sucking BID, inhaled the oral cavity;

Pediatric asthma diameter (10ml*8), 10ml tid po.

Medication analysis

Meng Lu Ste sodium is suitable for the prevention and long -term treatment of adults and children’s asthma, including preventing the symptoms of asthma during the day and night, the treatment of sensitive asthma patients in aspirin, and bronchial contraction caused by the prevention movement.

Due to the relatively low response of Soda Sodium, the tolerance and compliance of patients are relatively low due to safety, effectiveness, and adverse reactions. However, Meng Luste Sodium is a light -sensitive drug, which is unstable in encountering light, resulting in increased material increases. Therefore, the tablet with aluminum -plastic packaging materials is avoided; “Taking milk powder or other liquids outside the breast”, the purpose is to avoid light.

This prescription takes half a piece of adults to use Meng Lu Ste every day. The remaining half of the tablet is taken every day.

solutions

The dose of Mengru Ste is related to age:

1 to 2 years old, 4mg, Menglu Ste sodium granules;

2 ~ 5 years old, 4mg, Meng Lu Ste sodium chewing tablets;

6 ~ 14 years old, 5mg, Meng Lu Ste sodium chewing tablets;

Adolescents and adults over the age of 15, 10mg, Mengru Ste sodium tablets.

Therefore, the appropriate dose and dosage form should be selected according to the age of the child. This prescription should choose a preparation with a specification of 5mg.

Case II

Case

Children, female, 2 years old.

diagnosis

Myocardial disease, hypoccuscuria.

Medication

Potassium chloride cache tablets (0.5g*48), 0.25g BID PO.

Medication analysis

Potassium chloride tablets are commonly used clinically for potassium supplementation. Excessive potassium chloride intake can cause gastrointestinal discomfort, and ordinary tablets have a certain gastrointestinal irritation.

And potassium chloride medium -release tablets are a relatively ideal potassium supplemental formation. It is covered with mild release coated materials and covered with potassium chloride pupil cores. Therefore, if the completeness of the drug is destroyed, it will cause a large number of drugs. It has a strong stimulation effect on the gastrointestinal tract.

solutions

For children with low blood potassium or patients with insufficient dosage, or patients who cannot take nasal feeding oral nasal feed, they can consider potassium particles or oral solutions. No way of dosing such administration), you should avoid errors such as research and disassembly dosage.

Extension:

Slow -controlled release agents are long -lasting than ordinary tablets. The purpose of the preparation of constant speed release is to maintain constant blood concentration, and the effect is more long -lasting.

Non -constant -speed release preparations can avoid greater stimulation of the gastrointestinal tract and protect the gastrointestinal tract.

The vast majority of the laid -up mitigatically controlled agents are achieved by a single -layer membrane dissolving system and the penetration pump system. They cannot be opened, chewed or crushed.

However, there are also a few manufacturers’ slow -controlled release agents that achieve the slow release effect through multi -unit and unique microcapsule technology (can be used for half slices through obvious scratches). Chew or crush.

Inappropriate use, it is easy to cause a large dose of drugs to be quickly released, causing adverse reactions and even poisoning. The sustained -release tablets that can be taken are mainly available (different manufacturers of production processes may be different): single nitrate pearl ester slow -release tablets, ambermerolool sustained release tablets, sodium propyate sustained release tablets, octophyllium hydrochloride hydrochloric acid hydrochloric acid Ningchu tablets, card left double -polyba controlled interpretation tablets, and vytecar -hydrochloric acid chip. Case 4

Case

Children, male, February 18 days.

diagnosis

Congenital heart disease after surgery.

Medication

Di Gao Xin tablet (0.25mg*100), 0.03mg QD PO.

Medication analysis

Di Gaoxin is a strong -hearted drug, which is mainly used to treat various types of urgent, chronic mental dysfunction and atrioventricular tachycardia, atrial fibrillation or fluttering. Adverse reactions include gastrointestinal reactions (nausea, vomiting), cardiac toxicity (arrhythmia), neurotoxicity (yellow -green vision, blurred vision, conscious disorder, etc.).

Due to the low treatment index, small safety scope, and large toxic side effects. The amount of treatment of the drug is close to the amount of poisoning, it is easy to poison, and the lack of characteristic manifestations in clinical is difficult to distinguish from the performance of the original disease. Improper use will cause poisoning, and seriousness will even endanger life. The dose of this prescription is 1/8 ~ 1/7, which is difficult to divide the accurate dose, and there are hidden dangers of medication.

solutions

It can be applied to the preparation of the Gaoxin liquid, such as the high -tech oral solution and the ground high -tech agent. These preparations have the advantages of accurate dosage, easy grasp, and convenient use. They are suitable for children with small age and difficulty dosage dosage. At the same time, if there are conditions, the concentration of high -scholarship can be monitored to make it within the scope of effective blood concentration of 0.5ng ~ 2.0ng/ml.

summary

At present, domestic pediatric medication related issues are prominent, such as the lack of drug varieties and dosage forms, so it is matched with the needs of children with specific age, which is the hotspot of the current research and development of pharmaceutical dosage forms.

Similarly, when prescribing drugs for children, medical staff should combine the age of the child and the characteristics of the drug format to find a suitable administration solution for children to improve the efficacy of the drug, reduce adverse reactions, and ensure the compliance of medication.

references:

[1] Liu Teng, Xu Chunmin, Zhao Zhigang. The R & D and clinical application of sodium oxydride bicarbonate in Omeprazole [J]. Pharmaceutical evaluation, 2016, 13 (22): 13-16.

[2] The research progress of Wang Ruili, Zhao Libo, Zhang Xiaoyan. Children’s orally controlled interpretation agent [J]. Modern Pharmacy in China, 2020, 37 (13): 1661-1664.

[3] Lao Xianjie. Di Gao Xinxin agent [J]. China New Medicine Magazine, 1997 (04): 54-55.

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