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Genetics and pollution will increase the severity of asthma

According to researchers and collaborators in the United States, asthma patients with specific genetic characteristics show stronger symptoms after contacting traffic pollution. The research was published online in the magazine of “Scientific Reports”.

The research team is composed of scientists at the National Institute of Environmental Health Sciences (NIEHS) of the National Institute of Health and the University of Houston Rice. They find that the sensitivity of people who lack such genetic characteristics to have different sensitivity to traffic pollution. This work makes scientists closer to the use of precision medicine to prevent and treat diseases according to personal unique factors.

Common author, Dr. Shepherd Schurman, deputy chief physician of the Niehs Clinical Research Department, said genetic mutation, that is, the subtle difference of DNA makes everyone unique. He further added that in order to understand this concept, people should consider the written description of human genes as a protein.

“Everyone has the same genes, in other words, the same basic instructions, but among some people, a DNA base pair has been changed,” Schurman said. “This common genetic mutation is called a single nucleotide polymorphism or SNP. It can change the manufacturing method of protein and make individuals more or less susceptible to illness.”

The person in charge of Schurman is also the head of the Environmental Polynesia Registration (EPR), which is the DNA bank that provides volunteers for the study to provide the study. EPR research how SNP is combined with environmental exposure affects disease risks.

The two scientists, together with Niehs colleagues and lung disease experts Stavros Garantziotziotis, and the medical director of the Niehs clinical research department, checked four SNPs involved in biochemical pathways, which caused inflammatory response in the body. They explained that SNP is usually studied separately, but they want to know whether these SNPs and pollution exposure will aggravate the symptoms of patients with inflammatory diseases such as asthma.

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Schurman and GARANTZIOTIS collected SNPs of 2,704 EPR participants about asthma, severity of asthma symptoms and hospitalization addresses. Using SNP data, they divide the participants into three groups: high -reactors, or people who are very sensitive and inflamed to air pollution; those with low reactors, or people who are not sensitive to air pollution and are not easy to inflammation; People between them. With the help of the cooperatives of the University of Rice, the team used the address of the participants to calculate their distance from the main road. The classification of participants depends on whether they are more than or less than 275 yards from the main road. Data show that the level of air pollution rises near the main roads.

Researchers have found that patients with excessive reactions and places living in more roads with other people have the most severe asthma symptoms such as dyspnea, chest pain, cough and asthma. In contrast, the symptoms of asthma patients who are far away from the busy roads are milder symptoms. GARANTZIOTIS concluded that this work can greatly improve the quality of life of patients with asthma.


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