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Helicobacter pylori infection will not only cause stomach diseases!

Speaking of Helicobacter pylori, it seems that everyone knows more or less about it. It is said that it is a direct murderer that causes gastric duodenal ulcers and gastric cancer, but is it really the same?

The pylori in reality is more “abominable” than you think.

It is found that in addition to the gastric mucosa and cause gastric diseases, Helicobacter pylori can also be planted in oral and intestinal mucosa, causing oral and intestinal diseases. In addition, people also found that Helicobacter pylori infection will also increase the occurrence of a series of diseases such as respiratory system, hepatobiliary system, and cardiovascular and cerebrovascular system [1], but the mechanism has not yet been studied thoroughly.

Oral disease

As early as 1994, people found that the tooth spots and saliva of almost all the subjects were positive for bacterial. Later, through PCR technology, people found the existence of Helicobacter pylori in the mouth, and found that the incidence of Helicobacter pylori was positively related to children’s dental caries. More and more studies have shown that pylori infections are connected with the flat moss, recurrence of oral ulcer, periodontitis, and oral odor.

Through molecular biology technology, scholars have found that the mouth of the mouth pylori is the same bacteria in the gastric bacteria of the same individual, or the bacteria that recur in the stomach after eradication are the same bacteria. Therefore, some people suspect that the device of the oral Helicobacter pylori is the root cause of recurrence caused by the failure of the treatment.

Colonic tumor

Among the people with pylori infections, the incidence of colon tumors and colon cancer is significantly higher than those without infection.

Some researchers were detected in the removed polyps tissue through immunohistochemistry. Some people proposed that Helicobacter pylori was planted in the intestinal mucosa, causing damage to the mucous membranes, and stimulating the formation of adenoma. Ceductal adenoma is a type of predatic lesions. After 10-15 years, adenoma polyps will develop into colonic adenocarcinoma. It is also believed that Helicobacter pylori infection can cause an immune response to the body and stimulate the formation of colon tumors and colon cancer. Although the pathogenesis has not yet been determined, Helicobacter pylori infection can cause the incidence of colon tumors and colon cancer to be recognized by most experts.

Liver Disease

The stomach is rich in blood vessels and returns to the liver through the door vein system. When the gastric mucosa has a pylori, the inflammatory factors released into the liver through blood return can cause the incidence of liver disease to increase. Through the PCR method to detect the gene sequence of H. pylori in the hepatocyte tissue, it is found that the similarity similarity of the two is 90%, which indicates that the pylori infection may be related to the occurrence of liver cancer.

Gallbladder

Helicobacter pylori infection may lead to an increased incidence of cholecystitis or cholecoscopic stones.

The reason for consideration is that Helicobacter pylori enters the gallbladder through the ODDI sphincter retrograde, producing toxins to stimulate gallbladder mucosa, and inflammatory reactions occur. When the gallbladder mucosa occurs, it causes damage to gallbladder contraction function and bile stasis, forming gallbladder stones.

Cardiovascular disease

Studies believe that Helicobacter pylori infection is an independent risk factor for atrial fibrillation.

Helicobacter pylori infection can cause chronic inflammation of the atrium, induce atrium to reshape, and cause atrial fibrillation. In addition to atrial fibrillation, studies have found that Helicobacter pylori infection can cause atherosclerotic lesions, increasing the incidence of stroke, coronary heart disease, and myocardial infarction. The reason for consideration may be that the pylori screw pylori releases the inflammatory factor in blood. These inflammatory factors can accelerate vascular oxidation, promote the formation of arterial plaques and increase the unstable plaque, and eventually lead to the occurrence of atherosclerosis.

Respiratory diseases

Helicobacter pylori infection will not only increase the incidence of chronic bronchitis and chronic obstructive pulmonary disease, but also one of the factors that induce chronic obstructive pulmonary disease (COPD). Some scholars believe that pylori pylori and its secretion of toxins can directly enters the respiratory tract through gastroesophageal reflux, which can directly stimulate the airway mucosa, causing airway inflammation reactions and leading to a decline in lung function.

In addition to chronic bronchitis and COPD, H. pylori infection can also lead to an increased incidence of children’s asthma. It can be seen that children’s pylori infection must also be valued.

Metabolic system disease

Pneumaciacobacter pylori infection is two times that of the patients of Helicobacter pylori, and the further development of insulin resistance is diabetes. Studies have found that the level of empty blood glucose of pylori patients with pylori is also higher than negative patients. This shows that patients with pylori infection in H. pylori in the pylori have higher risk of diabetes.

The reason for consideration may be that chronic Helicobacter pylori infection stimulates the body to produce a large amount of inflammatory media and vascular active substances, increase the body’s oxidation stress state, and act on insulin signal pathways through multiple channels, which leads to insulin resistance. After further development of insulin resistance, insulin resistance is developed. That is diabetes.

Blood system disease

Iron deficiency anemia has an inseparable relationship with Helicobacter pylori infection, especially the refractory iron deficiency anemia with unknown causes.

Studies have found that more than 50%of the unknown reasons are refractory and iron deficiency anemia is accompanied by Helicobacter pylori infection, and about 75%of patients can be cured after eliminating Helicobacter pylori. Helicobacter pylori infection caused chronic atrophic gastritis caused a decrease in gastric acid secretion and reduced concentration of vitamin C in gastric juice, affecting intestinal iron absorption, and eventually leading to iron deficiency anemia.

Helicobacter pylori infection can lead to an increased incidence of specialty platelet reduction purposes, which is related to cross -immune response. In the Fifth National Helicobacter Cleefoxybly Prefecture Infection Hyb usage Report, it has clearly stated that patients with iron deficiency anemia and special platelet reduction purpura of unknown causes should be tested and eliminated Helicobacter pylori [2]. Although the bacteria are small, it cannot be underestimated by its destruction, which can almost cause the lesions of each system of the human body. Please do not treat Helicobacter pylori infection as a little thing that is unrelated!

references:

<!-2616: Stomach disease terminal page

[1] Fu Chengfeng, Yang Hongchang, Peng Tieli. The research progress of the relationship between pylori infection with gastric diseases [J]. China Practical Medical Journal, 2018, 45 (14): 125-128.

[2] The Chinese Medical Association Gastrointestinal Society H. pylori and digestive ulcerology groups, National Helicobacter Study Cooperation Group, Liu Wenzhong, Xie Yong, Lu Hong, Cheng Hong, Zeng Zhirong, Zhou Liya, Wang Jiangbin, Du Yiqi, Du Yiqi, Lu Nonghua. The Fifth National Helicobacter Cyne Cyne Infection Treatment Consensus Report [J]. China Gastrointestinal Magazine, 2017, 37 (6): 364-378.

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