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J hepatol: Mother is obese, and future generations are more likely to suffer from fatty liver

The changes in food quality and the sedentary lifestyle have led to high incidence of global obesity. More than half of the Chinese adults have overweight or obesity. Pan An and others from the School of Public Health of Tongji Medical College of Huazhong University of Science and Technology have published a series of articles about Chinese obesity in the June issue of “Liuye knife · diabetes and endocrine.” The article pointed out that the latest data of the “Report on Nutrition and Chronic Diseases of Chinese Residents (2020)” shows that more than 1/2 of the adults in my country are overweight or obese, and the overweight and obesity rates are 34.3%and 16.4%, respectively. Among children under the age of 6, 1/10 ultra -weight or obesity, overweight and obesity rates are 6.8%and 3.6%, respectively; among young people 6 to 17 years old, nearly 1/5 are overweight or obesity, and the overweight and obesity rates are 11.1%and 7.9, respectively. %.

With the popularity of obesity, the incidence of non -alcoholic fatty liver (NAFLD) has increased rapidly, and even affects 25%of the world’s population. Mother’s obesity is a risk factor for future obesity, type 1 diabetes and heart metabolic diseases.

Recently, a study published in the “Liver Diseases Magazine” published in the Karolinska School of Medicine and Harvard University stated that with the increase of the obesity rate of women of childbearing age, more and more young people have risk of fatty liver. Diabetes and hypertension are more common in metabolic complications of sexual fatty liver.

Researchers have determined 718 cases diagnosed as non -alcoholic fatty liver with age under 25. In these cases, 530 births before 1992 were excluded because there was no data about the mother BMI. In addition, 20 cases that are not born in Sweden, and 3 cases that are not single. Therefore, the sample includes 165 cases of non -alcoholic fatty liver, which match these cases with the 717 control group.

Most non -alcoholic fatty liver cases were diagnosed after 2010. The median age is 12.0 years old and 60.6%are men. Compared with the control group, the descendants of patients with non -alcoholic fatty liver patients have a low weight (3.35 kg in the median).

Data analysis shows that compared with the control group (8.4%), the mother’s obesity rate of non -alcoholic fatty liver offspring is higher (19.3%), and the mother’s BMI has a dose reaction effect. Compared with the normal mother of BMI, BMI, BMI The risk of NAFLD’s descendants of ≥30 kg/m2 is three times higher (AOR = 3.26). However, this risk is not statistically significant among ultra -heavy mothers, and she did not see statistical significance among mothers with insufficient weight (AOR = 0.84).

76 patients (46%) patients with non -alcoholic fatty liver are in line with severe non -alcoholic fatty liver standards (fibrosis: 71 cases of liver cirrhosis: 5 cases). BMI (AOR = 3.67) and ultra -heavy mothers (AOR = 1.94) will increase their offspring of severe non -alcoholic fatty liver.

In addition to the mother’s BMI, especially the social and economic factors, it is significantly connected with the non -alcoholic fatty liver of offspring. Compared with women born outside the Nordic countries, the risk of women born in Nordic countries with offspring of non -alcoholic fatty liver is significantly reduced (AOR = 0.35). Smoking ≥10 every day is related to the increase in the risk of offspring non -alcoholic fatty liver (AOR = 2.13), and the educational years are less than 10 years. Not significant (AOR = 2.22). The chance of obese mothers suffering from non -alcoholic fatty liver is equivalent to male (AOR = 4.22) and female offspring (AOR = 2.87). The sub -generation contains 65 women and 100 men.

All in all, in the early days when the mother’s pregnancy was higher, the risk of the descendants of non -alcoholic fatty liver was increased. The incidence of non -alcoholic fatty liver in the United States has doubled from the end of the 1980s to 2010. In addition, the second analysis of the study of Western Australia’s pregnancy queue found that 15.2%of the 17 -year -old young people have non -alcoholic fatty liver. Mother obesity is one of the risk factors of descendants’ non -alcoholic fatty liver.

Social and economic parameters, such as the low level of immigration mother, smoking, and education, they are all risk factors for descendants’ non -alcoholic fatty liver. People with low education level have higher BMI and type 2 diabetes. These factors also It will affect the prevalence of non -alcoholic fatty liver.

In the future, the prevalence of non -alcoholic fatty liver in children and adolescents will rise, and it is likely that it will continue until older. Previous research showed that the high BMI of the early life was related to the development of severe liver disease, and these results showed that obesity may also have adverse consequences at the age of childbirth, which further emphasized BMI, which can be used as part of the family planning.

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