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JAHA: Cardiac metabolism, lifestyle and nutritional factors related

Recently, a research article was published on JAHA, a authoritative magazine in the field of cardiovascular disease, and researchers conducted a two samples of Monder random studies to evaluate the connection between cardiac metabolism, lifestyle and nutritional factors and varicose veins.

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Researchers will be with height (positive control), weight index, type 2 diabetes, diastolic blood pressure and systolic blood pressure, smoking, drinking and coffee intake, 7 cyclic vitamins (A, B6, B9, B12, C, 25-hydroxyl vitamin D and E) and 5 circulating minerals (calcium, iron, magnesium, selenium, and zinc) are used as tool variables at a prominent level of the whole genome. The hereditary associated with varicose veins from the British Biological Bank (8763 and 352431 non -cases) and the FINNGEN Alliance (13928 and 153951 non -cases).

Higher genetic prediction height, weight index, smoking and circulating iron level are related to increased risk of varicose veins. The ratio of the ratio of 1 SD for each exposure is 1.34 (95%CI is 1.25-1.43), the weight index is 1.39 (95%CI is 1.27-1.52), and the starting smoking is 1.12 (95%CI is the ci is the ci is for it. 1.04-1.22), and the iron level is 1.24 (95%CI is 1.16-1.33).

Higher genetic prediction systolic blood pressure and circulating calcium and zinc level are correlated with the risk of varicose veins. After adjusting the height of genetic prediction, the correlation of systolic blood pressure has not continued. Each SD increased by blood calcium levels, or 0.75 (95%CI is 0.62-0.92), and the blood zinc level is 0.97 (95%CI is 0.95-0.98).

It can be seen that this study determines several changing risk factors of venous songs.

Primitive source:

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Shuai Yuan.et al.Cardiometabolic, Lifestyle, and Nutritional Factors in Relation to Varicose Veins: A Mendelian Randomization Study.JAHA.2021.https://www.ahajournals.org/doi/10.1161/JAHA.121.022286

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