Jama NETW Open: Low -fat plant diet can really reduce weight!
A large number of epidemiological studies have shown that overweight and obesity not only increase the risk of mortality, but also related to the occurrence of various diseases, but also affects almost every organ system of the whole body, including cardiovascular disease, diabetes, chronic renal diseases, multiple cancers, and multiple cancers, and multiple cancers, and multiple cancers, and multiple cancers, and multiple cancers, and multiple cancers, and multiple cancers, and multiple cancers, and multiple cancers, and multiple cancers, and multiple cancers, and multiple cancers, and multiple cancers, and multiple cancers, and multiple cancers, and multiple cancers, and multiple cancers, and multiple cancers, and multiple cancers, and multiple cancers, and multiple cancers, and multiple cancers, and multiple cancers, and multiple cancers, and multiple cancers, and multiple cancers, and multiple cancers, and multiple cancers, and multiple cancers, and multiple cancers, and multiple cancers. A series of skeletal muscle diseases and so on. However, overweight and obesity are not common among individuals with plant -based diet. Studies have shown that, compared with the omnivorous diet, people of plant -based diet have lower intracellular lipid concentrations, which indicates that by reducing the levels of lipid levels in the muscle cells or intracellular cells, mitochondrial activity and meal can be promoted Descendants. Therefore, the accumulation of lipids in myogenous cells and liver cells may also be related to insulin resistance and type 2 diabetes.
Recently, a study published in Jama NetW Open magazine discussed the effects of low -fat plant diet on overweight adult weight, insulin resistance, post -meal metabolism, and intramuscular and intracellular lipid levels. It was found that low -fat plant diet interventions can reduce energy intake and increase post -meal metabolism to reduce weight. These changes are related to reducing liver cells and intramuscular cells and increased insulin sensitivity.
This 16 -week random clinical trial was conducted in Washington, DC from January 2017 to February 2019. The researchers screened 3115 adults. In the end, 244 participants reached the standard, aged 25 to 75, the weight index of 28 to 40, and randomly distributed it at a ratio of 1: 1. The intervention group (n = 122) was required to follow the low -fat pure plant diet, and the control group (n = 122) was required to have no diet within 16 weeks.
The results showed that 87 % were women, 48 % were white, and the average age was 54.4 years. 16 weeks after the follow-up, the weight of the intervention group dropped 5.9 kg (95 % CI, 5.0-6.7 kg; P? <0.001), and the food thermal effect increased, and the control group did not change significantly (the difference between the inter-group effect was 14.1 14.1 %; 95 % CI is 6.5-20.4; P? <. 001). In the use of the steady -state model assessment index and predicted insulin sensitivity index (Predim) to assess insulin resistance, the steady -state model evaluation index decreases and the insulin sensitivity index (Predim) increases. The change of Predim is negatively related to changes in weight.
Diet also has a certain impact on the level of liver cells and muscle cells. In the intervention group, the level of liver cell lipids decreased by 34.4 %, from average of 3.2 % to 2.4 %, while the levels of intramuscular lipids were reduced from 16.4 % to 10.4 %. Within 16 weeks, these variables have not changed significantly in the control group. The changes in lipid levels in hepatocytes and muscle cells are related to changes in insulin resistance.
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In summary, low -fat plant diet interventions can reduce weight, which is obviously caused by its tendency to reduce energy intake and increase energy consumption after meals. At the same time, low -fat plant diet improves blood glucose levels and reduces insulin concentration. Some of the causes may be that the accumulation of lipids in liver cells and muscle cells is reduced.
Primitive source
Hana Kahleova， MD， PhD1; Kitt Falk Petersen， MD2; Gerald I. Shulman， MD， PhD2，3; et al.Effect of a Low-Fat Vegan Diet on Body Weight， Insulin Sensitivity， Postprandial Metabolism， and Intramyocellular and Hepatocellular Lipid Levels in Overweight Adults a Randomized Clinical TRIAL.JAMA Network. 2020; 3 (11): E2025454. Doi: 10.1001/JamaNetworkOpen.202020.25454
