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Jama: Painless delivery or anesthesia?Be careful with the risk of autism in the future!

Autism is a disease caused by brain development disorders. It is characterized by emotions. Words and non -verbal expression difficulties and social interaction disorders will have obvious interest in restricted behavior and repetitive actions. Parents generally notice their condition when they are two to three years old.

The symptoms will gradually increase, but some children with autism will have normal or close to normal early development stages (see children’s development) before the autism worsens. Special characteristics of the symptoms, such as the backstur of language.

A recent queue study found that extraordinarily analgesia during childbirth related to increased risk of offspring autism. In order to explore whether the epidural analgesia during childbirth will increase the risk of offspring autism, experts from the Gynecology and Obstetrics from the Gynecology and Obstetrics from the University of Copenhagen Hospital of Copenhagen, Danish have carried out relevant research, and the results were published in Jama magazines.

This national retrospective study determined all living children in Denmark from January 2006 to December 2013. The follow -up from the first birthday of the child to the end of December 2017. The main result of concern is the 10th revised version code of the international disease and related health issues of the Danish Psychiatric Center Registration Office or the State Patient Registration Office, and the diagnosis of autism spectrum disorder. The use of COX regression is estimated to be dangerous, and adjusts the synergistic variables describing mothers’ complications, social population factors, lifestyle, pregnancy, mental illness, psychotropic treatment, medical behavior, and self -closed family history.

The queue includes 479,178 children (233,405 girls [48.7%]; the median age of mother during childbirth was 30.9 [IQR, 27.6-34.2]); pain. The median follow-up is 7.0 years (IQR, 4.9-9.0 years). By the end of the follow-up, 6,428 children (1.3%) were diagnosed with autism. The incidence of autism diagnosis of children was 23.1 cases/10,000 years, while the exposure group was 185 cases/10,000 people (RR = 1.05 [95%CI, 0.98-1.11]). Internal analysis of secondary mothers (12.3%) of 5,9154 children (12.3%) estimates that the incidence of autism diagnosis of the exposure group is 208/10,000 years, and the exposure group is 171/10,000 years (RR = 1.05 [95% CI, 0.90-1.21]).

In this national Danish children’s queue study, the mother’s exposure to external analgesia during childbirth was not obviously related to the autism spectrum disorder of offspring.


Association of Labor Epidural Analgesia with Autism Spectrum Disorder in Children. Jama. 2021; 326 (12): 1170–1177. Doi: 10.1001/Jama.2021.1265555

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