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JCEM: The correlation between type 1 diabetic patient HBA1C level and endless pregnancy ending

Although the metabolic balance of patients with type 1 diabetes (T1D) is optimized, the maternal complications are still higher than the general population.

Recently, Journal of Clinical Endocrinology & Metabolism, an authoritative magazine in the field of endocrine and metabolic diseases, published a research article, which aims to evaluate whether the HBA1C level is associated with these complications.

678 T1D subjects in Lille Hospital carried out retrospective research (1997-2019). The researchers evaluated the relationship between HBA1C’s horizontal changes and complications. Composite standards (CC) are defined as at least one of the following complications: premature birth, signs of eclampies, greater than fetal age (LGA), less than fetal age (SGA) or cesarean section.

Among the 678 newborn, the median HBA1C before pregnancy was 7.2%(55 mmol/mol), 361 LGA (56%), 29 SGA (4.5%) and 504 non -premature babies (76.1%). The incidence of CC is 81.8%. HBA1C, which is higher in early pregnancy, is related to CC (an increase of 0.1%ratio (or) less than 1.04 [95%confident interval (CI) to 1.02 to 1.06]; P <0.001). HBA1C, which is higher in the third trimester, is related to CC (1.07 per 0.1%OR is 1.07 [95%CI is 1.03 to 1.10]; P 6.5%(48mmol/mol) and the third trimester of HBA1C <6%group and CC (OR for 2.81 [1.01 to 7.86]) and LGA (OR for 2.20 to 4.78] ) Increased incidence is related.

It can be seen that the rise in HBA1C levels is related to the complications of mother fetus. Although the metabolic balance is optimized during 3 months of pregnancy, the risk of LGA still exists for patients with early blood sugar disorders.

<!-2586: Diabetic terminal page

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