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Lancet sub -magazine: Bao moms pay attention!Obesity affects “growth” at different stages of children!

Children’s obesity is not only a risk factors for severe cardiovascular and cerebrovascular complications, but also continuously increase the incidence and mortality in adulthood. It is assumed that obesity in childhood will affect growth. According to reports, changes in linear growth (referring to second sexual characteristics, such as height, weight, etc.) are not good for adult cardiovascular risk, which means that the early linear growth in the early days is the negative results of the early linear growth and the health of cardiovascular health. related.

In addition, understanding the dynamic connection between body weight and growth in detail may help understand the complex relationship between energy balance, hormonal environment and growth in the development of obesity. Different studies believe that the growth of children with obesity has been promoted or suppressed. The differences in these observations may come from the different ages and development stages of children surveyed in these studies.

Previous research showed that obese children were tall at the age of 1-14. At the age of 2-8, the increase in BMI was related to the increase in the height of early childhood and the decrease in adolescence height, but it had nothing to do with the ultimate height. On the contrary, there are also reports that the ultimate height of obesity patients will be affected.

However, there is no comprehensive research that spans the entire age of children to adolescents to explore whether the growth dynamics of obesity children changes, and what changes and when it happens, which may point out the potential of the growth of obesity growth and changes. Endocrine mechanism. To this end, related research from the University of Leipzig’s Pediatric Research Center in Germany.

From 1999 to 2018, the population-based LIFE child recruited in Germany and the obese-rich Leipzig obese children (8629 children, 37493 measurement), researchers compared normal weight and obesity children (0- 20 years old) Height, growth and endocrine parameters. At the same time, from the independent German CRESCNET Registration (12,703 children), it was concluded that the height reference value of obese children was specifically targeted at the height of obese children.

Children with obesity are obviously higher than those of normal-age peers in the early days, and they have a maximum difference of 7.6cm at the age of 6-8. Obesity children have been slightly higher at birth, and have increased by 1.2 cm/year than non -obese children. This growth acceleration has nothing to do with the height of the parents, but accelerates with the increase of insulin-like growth factor-1 (IGF-1), insulin and leverin levels.

In adolescence, children with obesity show the decline in the high standard deviation scores of their origin. Adolescent growth is reduced by 25%, which is in line with the boy’s IGF-1 (reduced 17%) and testosterone (reduced 62%), and girls’ estradiol (decreased by 37%).

In addition, compared with normal body reorganization, serum leptin, insulin, and HOMA-IR of patients with obesity patients have increased significantly. However, there is no special similarities in terms of growth mode or growth rate. At the same time, no observation of FSH, SHBG, DHEA-S, TSH or FT4 is observed with any obvious connection with the growth rate.

It can be seen that in the different stages of obese children, the dynamic changes in linear growth are obvious. Prior to the occurrence of other severe complications, obesity affects the susceptibility, environment and/or endocrine factors of children’s early life growth.


Dynamic Alterations in Linear Growth and Endocrine Parameters in Children with OBESITY and Height Reference Values.

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