Liver cirrhosis causes secondary heart structure changes and dysfunction, called liver cirrhosis myocardial disease. However, the atrial fibrillation (AF) and other arrhythmias of patients with cirrhosis and other arrhythmia are lacking. Regarding whether hepatic cirrhosis is related to increased risk of atrial fibrillation, there are even some controversy.
Liver transplantation (LT) cases have been increasing worldwide, and advanced surgical technology and drug treatment have significantly improved the survival of patients. Cardiovascular complications now occupy the main causes of LT -related high mortality and incidence. It is reported that patients with AF are even more common in patients with LT. Pre -operation AF is related to increased risk of cardiovascular events during the perinatal period and may lead to death.
Researchers from the Department of Internal Medicine from the National University Hospital of Seoul, South Korea use the nationwide -based long -term follow -up data research to evaluate the risk of atrial fibrillation risks and their relationship with the mortality rate of patients with liver hardening patients. The study selected data from the national health insurance service of the national health insurance service in the national sampling queue database from 2004 to 2008 (N = 3596; the average age of 54.7 ± 12.3 years; male, 72.5%). Match a non -liver hardening individual control group at a ratio of 5: 1 (n = 17 980) at a ratio of 5: 1. Both queues followed up the incidence of atrial fibrillation and death, followed by 2013.
Research result
During the 9 -year follow -up, 113 patients (3.1%) patients with cirrhosis and 385 (2.1%) compared with the incidence (the incidence of 3.48 / 1,000 people and 2.16 / 1,000 people) had occurred.
? After adjusting the multiple factors, compared with the control group, the risk of atrial fibrillation of patients with cirrhosis (HR = 1.46; 95%CI, 1.18-1.80).
In the Asian group analysis, liver cirrhosis increases the risk of atrial fibrillation, especially for male patients who are young (age less than 65 years old) without complications.
Compared with the control group, the overall mortality rate of patients with cirrhosis (HR = 4.80, 95% CI: 4.47-5.15), and the increased cardiovascular mortality (HR = 1.37, 95% CI: 1.07-1.75). However, there is no significant correlation between the occurrence of atrial fibrillation between patients with cirrhosis (P = 0.188 and P = 0.260).
Analysis conclusion
Liver cirrhosis is an independent risk factor for atrial fibrillation, especially male patients who have no complications in the age of 65, emphasizing the importance of receiving heart assessment for patients with cirrhosis. At the same time, the occurrence of atrial fibrillation of patients with cirrhosis has nothing to do with increased mortality.
