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More than 150,000 patients participate!”Rainbow Plan” large -scale liver cancer early screening project has made new progress again

July 28, 2022 is the 12th “World Hepatitis Day”. The Southern Medical University Southern Hospital of Southern Hospital held the World Hepatitis Science Popular Science Popularity Video and Poster Poster and eliminating hepatitis Academic Association. The team of the liver disease center introduced the latest achievements of the “small shell” Bettillete Blocking Project and the “Rainbow Plan” large -scale liver cancer early screening project. The “Small Shell Project” has now covered 136 hospitals, 1593 doctors, and 32,442 pregnant women with hepatitis B in the country. The results of the interim analysis show that the HBV mother -to -child blockage rate has been greatly reduced; the “Rainbow Plan” has now collected 11 hospitals and 2 Internet Internet The platform, a total of 15,495 patients, focused on managing 20%of the high -risk population of liver cancer, and helping liver cancer early diagnosis.

World Hepatitis Science Popular Science Video and Poster Poster Poster and Elimination of Hepatitis

At the same time, a small science educational small video and 1 world hepatitis day propaganda poster were designed and produced by the Guangdong Provincial Committee of the Communist Party of China, the Guangdong Provincial Health and Health Committee, and the Southern Medical University Southern Hospital Liver Disease Center team designed and produced. It was officially released to the whole society on the same day, calling on the public to actively screen hepatitis B, regular medical examinations to understand liver conditions, chronic viral hepatitis patients received standardized treatment, and comprehensively curb the threat of viral hepatitis to human health.

There are about 80 million hepatitis B patients in China, but only 12%receive treatment

At present, there are about 80 million hepatitis B virus infections (referred to as hepatitis B) in China, of which only 20%have been diagnosed, and only 12%are received. Chronic hepatitis is an invisible killer, and the infected person can last for many years without symptoms, until hepatic cirrhosis and liver cancer occur, thereby missing the best time to treat. In Guangdong, liver cancer is 280,000 to 30,000 per year, and 80%of them are late, and about 90%of them are related to hepatitis B virus infection.

Professor Hou Jinlin, Director of the Department of Infectious Department of Southern Medical University, Southern Hospital

“As a doctor infected, I have seen babies who are infected with hepatitis B virus when they are born, and have seen men who are in the middle of the age died of liver failure. I have seen a family of four brothers who have lost their lives due to liver cancer. Viral hepatitis should work with the enemy and work hard. “Professor Hou Jinlin, director of the Department of Infectious Department of Southern Medical University, said that hepatitis B was mainly transmitted through blood, maternal and infants, and sexual transmission. For example, input blood and blood products contaminated by viruses, use uninterrupted syringes and needles (such as injecting drugs, etc.), invasive medical or beauty appliances (such as tattoos, ear piercing, etc.), shaver and toothbrushes; No protective behavior with infected people; pregnant women carrying viruses can transmit viruses to newborns. He reminded that there are suspected viral hepatitis symptoms or people who are susceptible to infectious, and they should take the initiative to check in medical institutions. The diagnosis of hepatitis B can be diagnosed by blood testing, mainly because hepatitis B surface antigen (HBSAG) test.

Table I diagnose the interpretation of the serum test results of hepatitis B and the corresponding action

Most acute hepatitis B virus infections are not easily detected. Only a small number of people will develop into acute hepatitis. Common symptoms include fever, jaundice, nausea, loss of appetite, vomiting, general fatigue, upper abdomen discomfort, diarrhea and urine. Part of the hepatitis B virus infection will evolve into chronic hepatitis. Under the long -term slowly damage of chronic hepatitis, hepatocytes have continuously circulated the process of necrosis -repair -renewal process, making the growth of new liver cells no longer rules, and the original structure of the liver becomes messy. Over time, the original smooth liver surface became rough and uneven, liver function became worse and worse, and continued to progress towards hepatitis-liver cancer trilogy.

The prevention and control of liver cancer should be “three sieves and tube”, and more than 150,000 hepatitis B patients participate in the “Rainbow Plan”

The latest cancer statistics show that liver cancer is currently ranked fourth in my country’s malignant tumor, and the number of malignant tumors ranked second. In 2020, Chinese liver cancer was new and 391,000 cases of liver cancer, respectively, respectively, accounting for 45.3%and 47.1%of global cases, respectively, and bearing almost half of the world’s burden on liver cancer.

Barcelona Clinical Staging of Livercancer (BCLC) and Phase A are found to be diagnosed with diagnosed liver cancer patients with a 5 -year survival rate of 86.2%. The diagnosis rate is related. At present, the early diagnosis rate of liver cancer in mainland China is less than 30%. Therefore, it is urgent to optimize the implementation of the risk of liver cancer risks for chronic liver diseases in mainland China.

“In the early stages of liver cancer, if patients with liver cancer who were diagnosed and received in time, their 5 -year survival rate could be as high as 86.2%, and the 5 -year survival rate of patients who received surgical removal was 56.9%. The net survival rate is only 14.1%. “Professor Hou Jinlin proposed at the meeting that the prevention and control of liver cancer should be” three sieves and tube “, that is, the screening of high -risk people with high risk of hepatitis, cirrhosis, and liver cancer to carry out early intervention and active prevention.

In order to increase the early diagnosis rate of liver cancer, since 2008, Professor Hou Jinlin team created a global chronic liver disease line, incorporated 11 forward -looking queues of 17,374 chronic liver disease patients, created and verified a cross -disease (hepatitis B, hepatitis C, non -virus). The prediction model (AMAP score) of the risk of liver cancer (AMAP) of the risk of liver cancer (Asian, Westerners). The AMAP score is constructed by the five common test indicators of patients’ age (A), gender (M), albumin-total bilirubin (A), and platelet (P), which can accurately predict the risk of liver cancer and recognize the recognition More than half of the extremely low -risk people (the incidence of liver cancer is less than 0.2%of the annual liver cancer) from frequent screening, which significantly reduces the economic burden of patients, saves medical resources, and focuses on high -quality medical resources to high -risk people with liver cancer. Liver cancer risk assessment tool (AMAP score) -Hexia cancer risk schematic diagram

Note: Patients with chronic hepatitis scan the above mini -program QR code, which can automatically calculate the risk of liver cancer.

It is worth noting that this tool is designed to estimate the risk of liver cancer in patients with chronic liver disease, not to diagnose whether patients with evaluated patients suffer from liver cancer.

Early diagnosis of liver cancer is a public health system project. Under the unified leadership of government departments, medical and health (defense) integration, comprehensive hospitals, community health service centers and other medical institutions closely collaborate, through training and technical counseling to make liver cancer make liver cancer Early diagnosis technology and management specifications such as high-quality resources sink; in the professional field, multi-disciplinary cooperation is needed to jointly realize the “pyramid” liver cancer screening management model that is integrated with the hospital-community.

Professor Luo Kangxian, a famous expert in hepatitis B prevention and control in my country

Professor Luo Kangxian, a well -known hepatitis B prevention and control expert in my country and Southern Medical University, said enthusiastically at the academic meeting, “I hope that by providing free early screening systems and reducing inspection costs and other means to help grassroots and rural people with high risk of liver cancer, Early treatment and early treatment. “

The “Rainbow Plan” project is actively exploring the hospital-community-physicalization management model. With the support of various hospitals across the country, it is currently being established in Guangzhou Southern Hospital, Shenzhen Southern Hospital, Zhuhai People’s Hospital, Ganzhou People’s Hospital, Ganzhou No. 1 Five People’s Hospital and other comprehensive pilots, and created the “Medical Union” community management model in Tonghe Street Community in Baiyun District, Guangzhou, Guangzhou, and Hongshan Street Community in Huangpu District. At present, the project has collected 11 hospitals and 2 Internet platforms, totaling 154,951 patients, and entered the first phase of data retrospective analysis. And as a means of liver cancer screening, the “Consensus Expert of Early Sieve Strategy for Liver Cancer” and “Guidelines for the diagnosis and treatment of primary liver cancer (2022)”.

“The World Health Organization proposed that the elimination of viral hepatitis in 2030 is like blowing the charge, and the Rainbow Plan is our new Long March of the viral hepatitis.” Guo Yabing, a professor of infection in the infection of the Southern Hospital, introduced that the Rainbow plan was in Ganzhou City, Jiangxi Province. The pilot of the Yudu base has been implemented for two years, and the “Yudu experience” has been formed. In order to further promote the experience across the country, on July 28 last year, the “Rainbow Plan” walked into Nyingchi Tibet, and in September of the same year, it was free for a 57 -year -old hepatitis B hardening patient. Intravenous diversion (TIPS).

Slow disease prevention demonstration base in the launching ceremony of the capital station

Through the “small shell”, the incidence of hepatitis B maternal and baby transmission is expected to fall to 0.5%

Unlike the “stock” of the “Rainbow Plan” focusing on the “stock” of patients with viral hepatitis, the “small shell” project is committed to controlling “incremental”, that is, how to block the spread of viral hepatitis.

“Hepatitis B is mainly transmitted through blood, maternal and infants, and sexually transmitted. Among them, pregnant women carrying viruses can transmit viruses to newborns.” Liu Zhihua, chief physician of the infection of Southern Medical University in the Department of Infectious Department of the Department of Infectious Department of Southern Medical University Infection is easier to develop into chronic hepatitis B than adults. Studies have shown that 90%of the infected newborns will evolve into slow hepatitis B, and the risk of slow -infected children at the age of five or below to slow hepatitis B is 30%to 50%. Secondly, the incidence of liver cirrhosis and liver cancer is high. Data show that 1/4 develops into liver cancer and cirrhosis related to HBV infection. Third, chronic infection has become a potential source of infection and a public health issue.

Liu Zhihua, chief physician of the Department of Infection of Southern Medical University Southern Hospital

“Adopt antiviral treatment for mothers plus infant vaccine B vaccine to block the transmission of hepatitis B mother and baby.” Liu Zhihua said, “hepatitis B maternal and child zero communication project” -Smark shell project The network has achieved good results, which has greatly reduced the spread of hepatitis B and baby.

It is reported that the hepatitis B maternal and child zero -communication project (small shell) project has been in the third stage. Only 21 of the hepatitis B mothers and babies in Baoan District, Shenzhen have been implemented in Shenzhen Baoan District. The second -stage data that was completed before showed that only 38 cases of hepatitis B mothers and babies were studied in 136 hospitals incorporated, and only 38 cases were blocked and failed, and the transmission rate of hepatitis B maternal and infant was 0.23%.

In June of this year, the World Health Organization updated the hepatitis B target in 2030, and it was clear that the incidence of maternal and infant transmission of hepatitis B virus should be reduced to less than 2%. Hou Jinlin said with confidence that my country can completely revise the goal to less than 0.5%.


(Edited/Ye Fang Correspondent/Provided by Ling Weiming/Hospital)

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