The aging of the rapid split tissue of cells is usually caused by the degeneration of the adult stem cells (ASCS) in it. Skin epithelial cells are an important system for studying ASC aging in such tissues. In addition, with the increase of age, the skin will also show prominent aging phenotypes, including white/thin hair, wrinkles and healing defects, but at present, we are not very clear about the molecular mechanism that drives these changes.
Skin epithelium has two main spectrum systems, namely hair follicles and hair follicles (HFS). HFS will go through the cycle of rest, growth and decline, which is driven by the circulation activation of hair follicles (HFSCS), which is mainly living in HF bulge. HFSC’s offspring is usually limited to HF, but it can also be split across the epidermis after injury to repair the hair follicles. This phenomenon is called the “spectrum infidelity” of HFSC.
Gene toxic stress is an important pathogenic factor for many tissues (including skin) aging. The premature failure of the genome stability or the genetic attack of the genes, such as ionizing radiation (IR) and the sun, can accelerate the emergence of skin aging phenotype. According to reports, the changes in extracellular collagen caused by DNA injury are the basis of the aging of physiological HFSC, and it promotes depletion of its exhaustion through the scales. But so far, we are not clear about the cell internal factors of the fate of medium -aging HFSC. In addition, it is also meaningful to understand whether there is a common mechanism in the process of wound healing and aging.
Recently, the researchers reported that the aging of mouse skin hair follicles stem cells (HFSC) was initiated by their inner MIR-31. This micro RNA can be induced by physical damage or gene toxic pressure, and in aging human skin epithelial cells It is also strongly raised.
Researchers use the mouse model and conditional tracing technology of convertible knockout, indicating that MIR-31 directly targets the CLOCK (a core day and night rhythm clock gene, and its disorders activate the Mapk/ERK class to eliminate induction through the scalpel induced induction HFSC exhaustion) has become a key driver for HFSC aging.
It is worth noting that this way through the MAPK/ERK inhibitors approved by conditional MIR-31 ablation or clinical approval can safely and effectively prevent skin aging, and to treat skin diseases caused by skin aging and other genetic pressure (such as such as skin diseases (such as such as such as skin diseases (such as Radial dermatitis) opened a promising treatment path.
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Yao et al. A stress-induced miR-31 – Clock –erk Pathway is a key driver and therapeutic target for skin aging. Nature aging (2021).