Obesity is a serious health threat worldwide. In the past three decades, the incidence of obesity and metabolic syndrome has risen to the level of epidemic disease, especially in Western countries. Obesity and related metabolic disorders are type 2 diabetes, heart and kidney diseases, and at least 13 kinds of cancers, including postmenopausal breast cancer, colorectal cancer, endometrial cancer, esophageal adenocarcinoma and gallbladder cancer. Recent studies have shown that obesity and breast cancer have a strong correlation.
Existing studies have shown that heat restrictions can improve the impact of obesity related to obesity and inhibit the progress of cancer, but the intervention measures are difficult to implement and maintained outside clinical clinical. Recently in a study published by Nature Communications, researchers test time limit feeding (TRF) method on obese -driven postmenopausal breast cancer mice models. The research results show that TRF has not restricted calories or reducing weight, which inhibits the growth of breast tumors enhanced in the two models. TRF can also reduce the metastasis of breast cancer to the lungs.
In addition, among the tumor gene model mice, TRF can delay the occurrence of tumors before obesity. It is worth noting that TRF increases the sensitivity of whole body insulin, reduces high insulin ledmia, restores the rhythm of day and night gene expression of tumors, and reduces the growth of tumors and insulin signal conduction.
It is important that the use of dirt nitrogenazole to inhibit insulin secretion can simulate TRF, and by implantation of insulin pump artificially increased insulin to reverse TRF, it shows that TRF is played by regulating high insulin ledmia.
Therefore, these data show that TRF may be effective in the prevention and treatment of breast cancer.