Multiple sclerosis (MS) is usually 20-50 years old; however, 3-5%of MS patients begin to develop symptoms before the age of 18. Pediatric multiple sclerosis was originally manifested as a high degree of inflammation, but then it took longer than adult multiple sclerosis to an irreversible disability. Although the milestone of the disability still had an average of about 10 years in advance.
MS etiology is considered a comprehensive role of genetic susceptibility, infectious exposure, other environmental and behavioral risk factors. In particular, low solar exposure, low ultraviolet radiation (UVR) exposure and low vitamin D state have been well described as an environmental risk factors for adult multi -sclerosis, and risks related to insufficient sun exposure in childhood. However, so far, the research on the exposure to the exposure of multiple sclerosis sun/UVR is mainly limited to the adult population.
Recently, some researchers analyzed the data of a multi -center case -in -law, which surveyed the environmental risk factors of children’s multiple sclerosis. Its goal is to explore the relationship between sun exposure (measured at the time of outdoor activity), ultraviolet radiation (measurement at surrounding ultraviolet doses) and the risk of multiple sclerosis in children. Based on these factors, it is known to the risk of adult multi -sclerosis, and the research assumes that in this pediatric crowd, low sun exposure and low ultraviolet exposure will be related to greater MS risks.
Children with multiple sclerosis and control groups recruited from multiple centers in the United States are matched in gender and age.采用多因素条件Logistic回归分析，研究出生前一年和确诊前一年夏季每天户外活动时间、使用防晒霜和夏季环境紫外线照射剂量与MS风险的关系，并调整性别、年龄、种族、出生季节、 Children’s skin color, mother education, smoking exposure, overweight, and Epstein-Barr virus infection.
After gender and age matching, 332 MS children (medium disease: 7.3 months) and 534 control children.
In a fully adjusted model, compared with the recent summer time for less than 30 minutes, longer outdoor time is significantly reduced to the probability of multiple sclerosis. 1 hour: The advantage ratio after adjustment = 0.48, 95%trusted interval [95%CI] 0.23-0.99, P = 0.001; 1-2 hours: the advantage ratio after adjustment = 0.19, 95%CI is 0.09-0.40, p <0.001).
The high summer environment UVR dose also protects MS (AOR = 0.76/KJ/M2, 95%CI 0.620.94, P = 0.01).
If this is a causal relationship, then the sun in the summer may have a strong preventive and protective effect on multiple sclerosis in the patients, and it can also play a good protective role in places with more sunshine.
文献来源：Sebastian P， Cherbuin N， Barcellos LF， et al. Association Between Time Spent Outdoors and Risk of Multiple Sclerosis [published online ahead of print， 2021 Dec 8]. Neurology. 2021;10.1212/WNL.0000000000013045. doi：10.1212 /Wnl.0000000000013045