New methods of diabetes are difficult to heal wound treatment, and close the magic weapon of Pandora’s magic box?
Guide: Diabetic foot disease is one of the important complications of diabetes. Among them, the most harmful harm to diabetic foot ulcers brings huge economic burden and pain in life. Data show that the risk of foot ulcers in diabetic patients in life is as high as 25%. The management of diabetic foot ulcers is very important for early screening and prevention, especially for early management and treatment of foot wounds and ulcers.
Due to the impact of various pathological factors, the wounds of diabetic patients are slower than that of the general population. Chronic difficulty healing wounds are the initiator of severe diabetes and foot disease, like Pandora’s box, once it has endless suffering. Therefore, the early control of the wound deterioration and finding a method of improving wound healing are of great significance to delaying or preventing the progress of diabetes. Recently, a research report entitled “Local Extracting Flubuitette, which can improve the healing of diabetic mice wounds” was published in Diabetes. This study put forward a new plan for improving the healing of diabetic wounds.
Researchers mentioned that the continuous inflammation of the affected area of diabetic patients and the redemption delay of wound epidermis are the main causes of wound healing difficulty. Studies have found that high -level serotonin plays an important role in the repair of human tissue. Selective serum re -absorbing inhibitors (SSRIS) can increase epitrium serotonin and help promote wound healing.
Flx (FLX), as a member of SSRIS, can selectively inhibit serotonin transfer body, block the re -intake of serotonin, extend and enhance the role of serotonin, thereby creating antidepressant effects. Therefore, FLX is usually used for the treatment of mental illness (such as multiple types of depression), which adopts a way of administration. So, can local use of FLX improve the healing of diabetic patients? The researchers launched a bold conjecture and tested on diabetic mice.
Research description
The research targets of this test are 11 weeks of weekly age and blood sugar value of 300mg/dl (pure convergence mutation DB/DB). Test mice were randomly distributed to the control group and treatment group. The researchers conducted a full -thick 8mm resection wound splint model treatment, and then conducted local treatment on the affected area [10nmol/L FLX, 100NMol/L FLX, 1umol/L FLX, 2%serum of the test group. The control group was in the control group. Use 5%polyethylene glycol (PEG)] for a total of 10 days. During the study, the researchers evaluated the healing of the mouse wound.
Researchers use in vitro scratch experiments to evaluate the ability of mice to form cell migration and wounds and epithelium. In order to minimize the scoring test scores and the potential deviation of the scoring results of the wound test scores and the wound -epithelium tissue assessment, the researchers adopt a blind way to collect, encodes, and scores the image of the mouse in the test group, and the collected data is performed. analyze.
Research result
The wound is epidalized and the movement capacity of the keratin to form cells is a necessary condition for wound healing, and the reduction of these two functions often leads to the difficulty of healing of chronic wounds. Therefore, whether the ability to improve these two functions can be used as the evaluation FLX whether Effective standards.
FLX improves wound healing: under the presence of serotonin, the percentage of the FLX treatment group healing the wound healing is: 10nmol/L group 60.6%; 100nmol/L group 62.0%(P = 0.01); 1umol/L group 67.0% (P = 0.001). Compared with the control group (52.2%), the 100nmol/L FLX group and the 1umol/L FLX group are significantly different.
FLX enhances the migration effect of keratin formation cells to promote the production of macrophages: Studies have found that FLX can enhance the migration effect of keratin formation cells and promote the production of macrophages in a local trauma environment.
FLX can promote the epithelialization of cells: the reconstruction rate of the mouse of the control group is 39.6%, and the reconstruction rate of the mice of the FLX treatment group is 66.2%, which has significant differences (P = 0.01).
Analysis conclusion
<!-2586: Diabetic terminal page
Studies have shown that local external use FLX (FLX) can improve the re -epithelization function of diabetic mice skin tissue, keratin to form cell migration capabilities, and reduce inflammatory response, and ultimately significantly improve the wound healing of diabetic mice. Animal experiments have brought gradient research results that more clinical trials will be conducted in the future.
FLX has been listed for many years, and has mature toxicology analysis and safety assessment. If the test is smooth, once you apply for a new indicator, the approval time will be shorter than other drugs, which can quickly meet the treatment needs. Researchers believe that the use of FLX local treatment will be a safe choice for chronic difficulty in diabetes and delaying or preventing the progress of diabetic foot disease.
