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Paste this insulin “plaster”, and diabetic patients finally do not need to get an injection!

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Intelligent insulin stickers, one day tube one day!

Insulin is an important weapon for the human body to regulate blood sugar balance. Diabetes patients generally cannot effectively produce insulin and/or cannot effectively use insulin. At this time, insulin is needed to help the body maintain the balance of sugar metabolism. Based on blood sugar, the amount of insulin dosage is required, but also the pain of injection.

To solve this problem, researchers at the University of California, Los Angeles recently invented a “smart insulin sticker” and experimented on animals. This kind of patch is like a plaster, one day, one day, one day! Research was recently published in the magazine of Nature Biometal Engineering.

The size of this pancreatic sticker is only equivalent to one coin, but hundreds of tiny needles are arranged neatly. These tiny needles are made of polymer materials that can perceive blood glucose levels, which can easily penetrate the epidermis to perceive the blood glucose level near the subcutaneous tissue. When blood glucose rises, concentration changes are detected and swelling, thereby realizing automatic response to blood glucose levels.

At the same time, the researchers mixed them with organic compounds with insulin and polymer when they made these needles, forming needles after light. When the needle is automatically expanded, the insulin inner load will be released automatically, spreading into the body, playing a role in reducing blood sugar. After the blood glucose is gradually returning to normal, the release speed of insulin will slow down to prevent the risk of hypoglycemia.

Researchers have proved the effects of blood sugar lowering the blood glucose effect of insulin patch in the diabetic mouse model and diabetic pig models. The current research results show that a coin -sized smart insulin patch is enough Normal blood sugar for hours, and can be replaced with continuous use every day. Because these micro -needle lengths are less than 1 mm, it can effectively reduce the trouble and pain of patients and improve the quality of life of patients.

Researchers pointed out that this patch deliver insulin by simulating the working method of islet cells when needed to intelligently regulate blood glucose. The next intelligent insulin patch may gradually move towards the clinic.

If this technology can be successful in clinical trials, it is possible to change the mode of diabetes therapy, free the patient from the trouble and pain of blood sugar, insulin, and make the treatment of diabetes as simple as plaster. In addition, this treatment technology may not only be used in diabetes, but also is expected to be applied to the management of other diseases.

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There are too many meat, too much to get sick!

A guide published last year on Annal of InternaL Medicine claims that there is no strong evidence that eating red meat and processing meat is harmful to health, but this guide immediately aroused people’s opposition, and even some people picked up this guide. Possible interest behind. (Recommended reading: The topic of the United States internal science published a post saying “red meat is harmless”, but was ridiculed by doctors …)

The two recent studies also opposed this view together that red meat and processing meat may increase cardiovascular events and risk of death. Excessive intake from meat that mainly from meat (SAA) that mainly comes from meat may increase metabolism. Risk of sexually transmitted diseases.

The research published in Jama Internal Medicine included data from six large -scale queues in the United States, involving nearly 30,000 participants, with a median follow -up time for 20 years. turn out:

Eat 2 more processed meat (HR 1.07, 95%CI 1.04-1.11), red meat (HR 1.03, 95%CI 1.01-1.06) or poultry (HR 1.04, 95%CI1.01-1.06) and cardiovascular. The risk of disease is related;

Eat 2 more processed meat (HR 1.03, 95%CI 1.02-1.05) or unprocessed red meat (HR 1.03, 95%CI 1.01-1.05) is also related to the increase in death risk. (Note: One is equivalent to 113g unpaid red meat, poultry or 85g fish; for processing meat, one is equivalent to 2 bacon, 2 small sausages or 1 hot dog.)

Another study published on Eclinical Medicine’s research on SAA intake from the main meat meat. Studies have shown that most Americans’ daily SAA intake far exceeds the average amount. The research using Nhanes III (Nhanes III) evaluated the relationship between SAA intake and chronic disease risks. The study surveyed the risk score of the heart metabolic disease, the total SAA intake, the MET) intake of the total SAA intake, and the cysteine ​​(CYS) intake found that the American SAA intake of the average amount required 2.5 times.

The higher SAA, MET, and CYS intake independent of protein intake, which is related to the increased increase in risk scores of composite metabolic diseases. At the same time, it is also related to serum cholesterol, glucose, uric acid, serum urea nitrogen, insulin and HBA1C level (P <0.01). At present, people's SAA intake is too much. In order to reduce the intake of SAA, the protein of plant sources should be selected more, not meat foods. Researchers pointed out that although the impact of diet on our body may take decades to appear, our diet habits will definitely affect our health. No kind of food can increase our risk of illness, but a little risk of everyone means that there are countless cardiovascular metabolic diseases in the future, and these diseases can be avoided.

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Women drink more yogurt, healthy and longevity!

Yogurt can provide people with a variety of nutrients such as protein, calcium, magnesium and vitamin B12, and may also be composed of increasing the diversity of intestinal probiotics and improving intestinal flora. Therefore, yogurt can prevent chronic diseases and improve people’s health. It seems to be a conclusion of water. However, there seems to be no determined evidence that eating more yogurt can improve health and reduce people’s risk of death.

In order to solve this problem, the recent American research uses the data of the two large queues to evaluate the effect of ingested yogurt and find that women eat more yogurt or reduce the risk of death.

The study published in the American Journal of Clinical Nutrition was included in the 40,278 participants in the 82,348 women in nurse health research. These participants did not have a history of cardiovascular disease or cancer at the beginning of the study. The researchers obtained their yogurt intake through the questionnaire survey and accumulated more than 3.35 million years of follow -up materials.

It was found that a total of 2,831 women and 12,397 men died during the follow -up period. Compared with people who do not eat yogurt, the frequency of edible yogurt ≤ 1/week (HR 0.89, 95%CI 0.86-0.93), 1-3 times/week (HR 0.85, 95%CI 0.81-0.89), 2-4 Times (HR0.88, 95%CI 0.84-0.91) and> 4 times/week (HR 0.91, 95%CI 0.85-0.98), the risk of death has ranged by 11%-15%. However, it is worth noting that this change does not have a dose-reaction relationship (P For Trend = 0.34). Yogurt seems to be more useful for men. No matter how much yogurt the men eat, the risk of death will not be reduced.

<!-2586: Diabetic terminal page

Can yogurt prevent disease? Studies have found that eating more yogurt can reduce the risk of death of cancer 13%(HR 0.87, 95%CI 0.78-0.98; P for Trend = 0.04), but it cannot reduce the risk of cardiovascular death (0.92, 0.79-1.08; P for Trend = 0.41). Use 1 nut (28g) or whole grain (28g) instead of 1 yogurt (245g) can further reduce the risk of death, but with 1 red meat (85g), processing meat (28-45g) or milk (8OZ (8OZ) /236ml) or other dairy products (1OZ/28G) instead of yogurt may increase the risk of death.

Researchers pointed out that although yogurt is mainly fermented by probiotics such as eosinophils, cheese, and bisidobacterium, it is impossible to analyze the ingredients of various yogurts in the study and the type and concentration of probiotics cannot be determined. In addition, the specific types of yogurt ingested by participants, such as low -fat, skimmed or sugar, and the risk of death are not clear. Although the study found that women’s edible yogurt can reduce the risk of death and cancer death, because there is no clear dose-reaction relationship, it still needs to be treated with caution.

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