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PLOS Med: The risk of anxiety and depression in patients with breast cancer is higher!

According to data released by the International Cancer Research Agency (IARC) in December 2020, breast cancer has become the world’s most common cancer in the world. However, women with breast cancer may experience a series of life problems, such as concerns about cancer recurrence, career selection or economic difficulties, and have a serious negative impact on mental health. However, there is almost no evidence in large -scale research that can quantify the history of cancer on people’s long -term mental health.



Recently, a study published in the PLOS MED magazine shows that compared with women without cancer, there are risks such as anxiety, depression, sleep, sexual dysfunction, fatigue, and pain of breast cancer survivors. In the 2 and 4 years after the diagnosis, the incidence of anxiety and depression in patients with breast cancer increased significantly, and fatigue, pain and sleep disorders increased 5-10 years after diagnosis.

In this study, a matching queue study was conducted through the regular collected data collected by junior health care in the United Kingdom to quantify the history of the history of breast cancer and depression, anxiety and other mental health -related results.研究人员收纳了来自1988年至2018年期间,临床实践研究数据库(CPRD)中57571名乳腺癌女性,平均年龄为62岁,然后根据年龄、初级保健实践和数据与医院数据源链接的资格,与230067 women who had no cancer had a 1: 4 match. Evaluate the results of breast cancer survival and different mental health through COX.

It was found that the survival rate and anxiety of breast cancer (the risk ratio (HR) = 1.33 after adjustment; 95%confident interval (CI): 1.29-1.36; P <0.001), depression (1.35; 1.32-1. 38; P < 0.001), sexual dysfunction (1.27; 1.17-1.38; P <0.001) and sleep disorders (1.68; 1.63-1.73; P <0.001) are positively correlated, but it is related to cognitive dysfunction (1.00; 0.97-1.04; P = 0.88 ) There is no significant relationship.疲劳(HR=1.28;1.25-1.31;p<0.001)、疼痛(1.22;1.20-1.24;p<0.001)、接受阿片类镇痛药(1.86;1.83-1.90;p<0.001)和致命性和非Fatal self-injury (1.15; 0.97-1.36; P = 0.11) is also positive, but the CI is wide, and the latter's relationship is not statistically significant.

It is worth noting that the HR of anxiety and depression decreases over time, but the risk of anxiety and depression increases by 2 to 4 years after the diagnosis of cancer. Pain and sleep disorders have improved 5-10 years after diagnosis. Patients with breast cancer are younger, depression, cognitive dysfunction, pain, and higher HR using opioid analgesic drugs and sleep disorders.

In summary, patients with breast cancer are related to a variety of bad mental health. The risk of bad mental health increased significantly before/after the diagnosis and during treatment. Therefore, early diagnosis and management of patients with breast cancer may reduce the long -term health risks damaged by the disease.

Primitive source

Helena Carreira ,Rachael Williams,Garth Funston,Susannah Stanway,Krishnan Bhaskaran.Associations between breast cancer survivorship and adverse mental health outcomes: A matched population-based cohort study in the United Kingdom.Plos Med.2021. https://doi.org /10.1371/Journal.pMed.1003504

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