Stroke: In -brain stroke, aspirin’s treatment fails, what antibody schemes are there?
In the United States, more than 40%of adults over 70 years of age take aspirin for primary prevention of cardiovascular disease, and more than 70%of patients who have a history of cardiovascular disease in the history of cardiovascular disease take aspirin every day.
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Although aspirin is often used for cardiovascular disease and stroke prevention, many patients taking aspirin therapy still have ischemia (so -called aspirin failure). Although the dose of aspirin is often considered, the second drug is increased, or another antiplatelet drug is used, there is no evidence to indicate the superiority of these methods.
In this way, the university of texas Southwestern Medical Center Jay B. Lusk et al., Evaluated the incidence of Aspirin in the elderly patients with acute ischemic stroke, and described the antiphantal treatment of anti -thrombosis for the second level of stroke when they were discharged from the hospital. Prescription mode.
They use the data of the American Heart Association Get with the Guidelines Stroke Registry to describe the treatment model of the bearing anti -thrombus treatment model of the Bed Medical Insurance beneficiaries from 1734 hospitals in the United States from October 2012 to December 2017. These beneficiaries are in Take aspirin before the stroke and be discharged alive.
Among the 261 survivors of ischemic strokes, 100 016 (38.2%) took aspirin single -medicine treatment before stroke. Among them, 44.4%of patients still took aspirin single drug treatment (20.9%81 mg, 18.2%were 325 mg, and 5.3%were other or unknown doses).
The most common treatment options are dual anti -platelet therapy (24.6%), followed by clopidogre single drug treatment (17.8%).
The remaining 13.2%of patients used oral anticoagulants with aspirin/dual -dongdamo, Huafarin or non -vitamin K antagonists. They used or did not use antiplatelets at the same time, or there was no anti -thrombosis treatment at all.
The significance of this study is to find that in patients with ispicidal stroke who receive aspirin prevention and treatment, nearly half of patients were treated with aspirin single drugs after discharge, and they did not change the anti -thrombosis drugs. Single medicine treatment, double antiplatelet therapy, or other non -commonly used drugs.
These findings emphasize the necessity of future research to determine the best management strategy of this very common and complex clinical situation.
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Original source:
Lusk JB， Xu H， Peterson ED， et al. Antithrombotic Therapy for Stroke Prevention in Patients With Ischemic Stroke With Aspirin Treatment Failure. Stroke. Published online October 27， 2021：STROKEAHA.121.034622. doi：10.1161/STROKEAHA.121.034622
