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The man was 40 years old and faced the “sperm crisis”!

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The father is more than 40 years old, so his descendants may be susceptible to autism, schizophrenia, emotional disorders and epilepsy.

The infertility caused by women is well known to the public, and men can produce active sperm from adolescence to old age. Will men have an impact on fertility?

In addition, is the descendants of the elderly men’s breds different in terms of physical and mental health?

The answer is yes, Professor Sun Fei of the Red House Obstetrics and Gynecology Forum specially invited to the Dean of Nantong University Medical College of Medicine, and shared his research results with us in the old age and fertility of men and health.

Regarding the age, 40 years of age is a watershed. Professor Sun gave him an example of a 40 -year -old male patient. He had already had one son. After the second child policy was open, he decided to ask for another. It is impossible to conceive his wife at a time.

As a result, the inspection found that he was already serious, weak, and even no sperm!

Coincidentally, there was a couple who came to infertile consultation. At first, the inspection found that the quality of the husband’s sperm was normal, and the wife’s conception was not good. After two years of treatment, the wife adjusted, but the husband had sperm quality Severe decline. Men’s sperm quality changes are so big with age.

Sperm crisis may not be far away

In fact, not only these two examples mentioned above, the global sperm quality has declined.

France’s study in 2017 involving 26609 infertile couples found that sperm density dropped by 32%and normal sperm morphological rates fell by 33%. The quality of sperm is at a rate of about 1.7%per year. At this speed, after several years, the sperm crisis is not alarmist. In addition, due to the decline in global sperm quality, the standard for normal sperm has also decreased. In the past 1ml semen, one billion sperm could be considered normal. Now 1ml can be counted as 15 million to 20 million. normal.

So what are the interference factors that affect the quality of male sperm?

Harmful chemical interference in the environment, such as formaldehyde, amine dyes, smoking, stress, obesity, etc.; And the accumulation of gene mutations in genetic factors may affect the quality of sperm. Therefore, at the age of 20, sperm is normal. At the age of 40, sperm may be affected by the accumulation of the above aspects, which leads to infertility caused by male factor.

Can fertility does not mean healthy fertility

There are essential differences between the offspring that can be born and can have health and health.

So, will the descendants of elderly men have the impact?

In recent years, epidemiological studies have found that their father is older than 40 years old, so its descendants may be susceptible to autism, schizophrenia, emotional disorders and epilepsy.

Among them, autistic factors related to male factors have been discovered:

Men’s 15Q chromosome area of ​​UBE3A genes lack of

Has-Mir-21-3P in the men’s brain tissue of autism produces changes

Father HSV infection increases the risk of autism for autism

Elderly men are independent risk factor for descendants of autism

In other words, the elderly factor can cause the ending of adverse fertility, and the elderly male factors should be paid attention to!

Mouse experiments have confirmed the impact of age on future health

Professor Sun’s team verified such views through some experiments. The experiments were used as the experimental group in June, which was equivalent to 40 years of human beings. In April, mice were used as a control group, which was equivalent to 20 years of human beings. It was found that the F1 generation and F2 generations of the elderly group had the characteristics of autism. In addition, in October and December, mobilized mice were used as experiments in the experiment of February. In the experiment of the control group, the F1 generation of the elderly male mice had the tendency of autism.

In addition, the team also conducted conditional fear experiments. Normal individuals have a deep impression on the memory of horror, so as to avoid potential dangerous danger in the future. The research of Professor Sun found that his father’s age significantly affected the fearful memory of the subdivine. The method of this experiment is that the training during the training allows mice to collect electricity stimulation, and at the same time hear a certain frequency sound, detect its stagnant time, is in popular time that is scared. In the test period, only the sound of mice hear the sound during training, but it does not stimulate it. If the mouse has a fear of fear, it will also show stagnation. It was discovered that the stagnation time of the elderly mice became significantly shortened, which means that the children of the elderly fathers may have certain defects in fear memory. However, the age and fearful memory of the mother are not related.

The team also conducted the water maze experiments to test the space learning and memory of mice for different aged groups. The experiment first trained mice to find the platform hidden in the water on the water, and through the platform mice, they could escape from being flooded. During the test, testing the time of the mouse found the time used by the platform. As a result, the older the father was older, the worse the ability to learn and memory in the space.

Not only in terms of memory, the research team also found that the children of the elderly male mice have adverse effects in terms of sugar metabolism disorders, high sugar intolerance, and exogenous insulin.But if these children can bred in appropriate age, their descendants’ defects in the above aspects can be avoided.Therefore, in the face of the challenge of reproductive health, although various auxiliary reproductive technologies can help the dream of fertility, for men, elderly fertility may still have adverse effects on the spirit and physiological health of future generations.

Therefore, advocating for age is not only important for women, it is equivalent to men.

First of this article: obstetrics and gynecology channels in the medical community

Speech expert: Professor Sun Fei Professor of Nantong University Medical College and Professor of International Peace and Child Health Hospital affiliated to Shanghai Jiaotong University School of Medicine

Author of this article: Red House Forum “Medical Obstetrics and Gynecology Channel” Reporting Group-Zhou Xiaobo

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Picture of this article: From the speaker PPT

Editor in charge: Guo Yan

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