Often, there are mothers who are in a hurry to ask themselves to take some drugs. They will be eaten by the child through milk, but they will not feed and worry about returning milk. I don’t know what to do. You can nurture your baby more at ease.
As we all know, many drugs can be excreted through milk, and some of them may have adverse effects or damage to the breasts. Therefore, whether to continue breastfeeding during breastfeeding women and medication is a question worth paying attention to. In clinical treatment, we should correctly guide breastfeeding women’s medication from various aspects.
When breastfeeding women are used, they often only focus on whether drugs affect milk secretion, rarely consider the effects of drugs on babies, or they do not know which drugs have an impact on babies. In fact, many drugs can enter the baby’s body with the mother’s milk, which affects the breasts. Although some drugs enter the concentration of milk, they have a great scourge for their childish and soft breasts.
Factors affecting drugs to milk
1. Drug dynamic characteristics Breastfeeding women have different characteristics of drug dynamics due to their physiological functional characteristics. Drugs combined with protein in maternal plasma cannot be trapped in breast milk, and only free drugs can be transferred. The plasma concentration of free -type drugs depends on the dose and the biological transfer process in the body. Drugs with high biological utilization, low protein binding rate, low surface distribution volume, and long half -life have a large amount of milk transfer to milk. In response to the characteristics of their drug dynamics, in clinical medication, some new drugs that are only listed should be familiar with the pharmacodynamic characteristics of these drugs, comprehensively consider, and use the medicine carefully.
2. The impact of the drug to solve the constant of the drug is related to the ionization of the milk. Most drugs are weak electrolytes and can be more or less ionized. Only non -ionic drugs can pass the biofilm. Most of the drugs used clinically are weakly acidic or weak alkaline salts. Usually non -fat -soluble drugs are more difficult to transfer to milk, and drugs with high acidity from high constants are exactly the opposite. In the plasma, it is difficult to change the fat -soluble changes in plasma, and it is easy to transport to milk. Therefore, the concentration of weak alkaline drugs in milk is higher.
3. The effect of the drug concentration gradient. Drugs must pass the blood-milk barrier from the mother blood into the milk. Pharmaceutical concentration gradient between blood and milk is the main factor for drug transfer to milk. The larger the drug concentration gradient, the more transfer. Evaluating the effects of drugs on breasts can be measured by calculating the concentration of drugs in milk and breasts’ plasma. Drug molecular quantity, low protein binding rate, high fat -soluble, high degree of non -ionization, can easily enter milk.
The impact of some commonly used drugs on newborns
1. The concentration of antibiotics and other antibacterial drugs in different antibiotics varies greatly in milk, and allergies can be seen at occasionally. Repeatedly contacting antibiotics in the breasts can easily lead to the production of drug -resistant strains.
Penicillin and cephalosporin antibiotics can enter a small amount of milk, and they must be alert to the normal enteric path flora that may affect the breast. The trace penicillin or ammonia crickets in the milk can cause allergic reactions to the breast and can cause life -threatening. Tetracycline can damage the bones and enamel of milk, chloramphenicol, which causes potential danger of bone marrow suppression and gray baby syndrome. The concentration of erythromycin dairy is higher than the concentration of blood medicine for lactating women, which can easily lead to breast bile bile. Substation jaundice. Sulfa drugs can be excreted through milk except those who are not easy to absorb orally, and the concentration of drugs in milk is higher than the concentration of breast milk, especially for premature babies, weak bilirubin ledmia, and G-6-PD deficiencies. Baby breastfeeding is dangerous.可 Nonone drugs can cause hemolytic anemia and alien cigarettes to cause breast liver poisoning. Ketonazole and fluoronazole can be similar to the concentration of the drug in the absorption of milk and milk, which may cause damage to the milk. For women with external preparations containing such drugs, women should be carefully considered when applying.
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2. The central nervous system inhibitory drugs of Apzzzzzzzzzzzzzzzzzzzzzzole, Aiszolun, and Di Xizheng and other drugs for treatment of anxiety and sleep disorders. Long -term medication of breasts may cause dizziness and abstinence symptoms of sleeping and breast -stopd. There is a potential adverse effect. Because these drugs can be absorbed by milk, breastfeeding should stop breastfeeding when applying such drugs.
3. Anti -hot -town analgesic women’s application of analgesic drugs, especially weak analgesic drugs, accounts for a certain proportion. Many traditional Chinese medicine compound agents that treat winds and colds contain a certain percentage of heat -relieving analgesic components. Such as acetylphenol, non -Nicotine, Antidelin, aspirin, bisloflochic acid, and cosin. Aspirin can inhibit the bone marrow of the dairy, which can cause liver damage to the hypogonate, and bislchromol acid can cause hematuria in babies. When lactating women, when applying a Chinese medicine compound preparation containing the above western medicine ingredients, they should consider carefully and read the drug instructions carefully to understand their composition content as much as possible. Some addictive analgesic drugs such as morphine and reasons are highly distributed in milk. Breastfeeding women with opioid addiction can also be addicted to breastfeeding babies. Newborns are highly sensitive to such drugs and can cause respiratory suppression. Therefore, breastfeeding women should definitely ban.
(Editor in charge: Zhao Yuanyuan Intern editor: Zhang Yumei)