Three studies revealed: Is aspirin, aerobic exercise, physical quality index and the prognosis of breast cancer?
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The results of the United States have shown that they can avoid 34.6% of breast cancer after menopause can be avoided when treatment is reduced, alcohol, breastfeeding and menopause without using hormone treatment. Lifetime, obesity, and fertility are important influences of breast cancer. In addition, understanding of the impact of related risk factors on patients with breast cancer is also of great significance. This article is an excerpt from the three studies of common factors such as lifestyle such as lifestyle.
01
Low -dose aspirin has nothing to do with the prognosis of breast cancer
background
Previous studies have shown that small -dose aspirin may improve the prognosis of breast cancer. This study aims to evaluate the correlation of the clinical characteristics of the prognosis of aspirin and breast cancer.
method
Study and collected three regions from Sweden, from April 1, 2006 to December 31, 2012, it was diagnosed with 21,414 patients with phase I ~ III breast cancer. And further collected information such as low -dose aspirin and the cause of death before and after the diagnosis of breast cancer. In another queue analysis, 621 patients diagnosed with patients with stage IV breast cancer to death, and used multi -variable Cox proportional risk model to evaluate the correlation with aspirin.
result
Among the patients with stage I ~ III, 2660 cases (12.4%) began to take low -dose aspirin not long ago during breast cancer diagnosis, 4091 (19.1%) patients took it during the follow -up period, and the follow -up time was 3.8 years. Among them, there is no correlation between the use of aspirin and breast cancer. The risk ratio (HR) before diagnosis is 0.93, and HR = 1.00 used after diagnosis. Similarly, the use of aspirin is also not related to the risk of first recurrence/metastasis in stage I ~ III (HR = 0.97). However, in the Asian group analysis, the mortality rate of low -dose aspirin after diagnosis is negatively correlated with the mortality of patients with phase I breast cancer (HR = 0.53). Among patients with phase IV breast cancer, taking aspirin has nothing to do with breast cancer to death (HR = 0.91).
in conclusion
This is a large -scale queue study based on the crowd. The results show that the use of low -dose aspirin before and after breast cancer diagnosis has no correlation with the overall adverse prognosis risk of breast cancer. However, potential benefits were found among patients with phase I tumors, which is worth further studies.
02
Aerobic exercise can improve the physical condition, skeletal health and quality of life in patients with overweight and obese breast cancer
background
Exercise is an effective strategy to improve the quality of life and physical quality of patients with breast cancer. However, few studies pay attention to early survival, ethnic minorities, lack of exercise and obese women and bone health. This study evaluated the impact of patients with gymnomics and resistance to patients with different races, lack of exercise, overweight or obese patients with 16 weeks of aerobic exercise and resistance.
method
Within 6 months after completing the auxiliary treatment, the physical health, bone density, bone density, bone biomarkers, serum concentration and quality of life were evaluated during the 6 months after completing the auxiliary treatment. Essence Sports intervention includes moderate intensity (maximum heart rate 65%~ 85%) aerobic and anti -resistance exercise, 3 times a week for 16 weeks. Repeat the difference in the end of the patient’s ending with a hybrid model.
result
运动干预后，运动组的生活质量优于常规护理（组间差异：14.7，95％CI：18.2，9.7；P <0.001），在抗疲劳（P <0.001）、抗抑郁（P <0.001）、 The maximum oxygen volume (P <0.001), muscle strength (P <0.001), bone calcium (P = 0.01) and BSAP (P = 0.001) are better. During the three -month follow -up, compared with the baseline, the report ending and physical indicators of all patients in the sports group have significantly improved (P <0.01).
in conclusion
The study aimed at solving the metabolic syndrome of patients with overweight or obesity breast cancer patients in ethnic minorities showed that the 16 -week aerobic and anti -resistance exercise can significantly improve the quality of life and physical condition of patients. And nursing standards.
03
Analysis of Asian women’s crowd: Breast cancer risk factors and the correlation between survival/recurrence
background
The evidence from the research of Western crowds shows that the impact of risk factors related to lifestyle on the prognosis may depend on molecular subtypes. This study aims to evaluate whether the risk factors related to pre -diagnosis of pre -diagnosis in Asian people are related to the clinical results of molecular typing dependencies.
method
In this group of crowd -based cases, the risk factors of breast cancer at 3012 infiltrated breast cancer patients in Sarawak, Malaysia, and the correlation between the mortality rate (ACM) and the 5 -year recurrence rate of 10 years. During the median follow -up to 24 months, 579 deaths and 314 recurrences were followed. The immunohistochemical logo defines hormone receptors and human epidermal growth factor receptors 2 and tissue grades (Luminal A, B, HER-2+, three-negative). The correlation between the risk factors and ACM/recurrence of the sub -type specific COX regression model is adopted.
result
Studies have discovered the heterogeneity of tire/breastfeeding, the first full moon pregnancy age (FFP), family history, physical quality index (BMI), and tumor subtype (P <0.05).Among patients with type A, the age of the early menstrual tide (HR (95% CI) ≥15 vs 12 years = 2.28 (1.05, 4.95)] and the lighter weight [HR (BMI) 30 VS <21 years = 0.20 (0.04, 0.90)] and the prognosis is good. Generally, the results of the recurrence of breast cancer are similar to this..
in conclusion
Studies have found that breastfeeding, BMI, and prognosis of patients with Luminal A breast cancer are consistent with the results of Western people.A forward -looking research needs to verify the changes in lifestyle, especially BMI to improve the prognosis of patients with type A breast cancer patients.
